Treatment of an Infant With Severe Acute Refractory Immune Thrombocytopenic Purpura Using Combination Therapy Including Rituximab

被引：3

作者：

Iesato, Kotoe ^{[1
]}

Hatakeyama, Naoki ^{[1
]}

Yamamoto, Masaki ^{[1
]}

Hori, Tsukasa ^{[1
]}

Inazawa, Natsuko ^{[1
]}

Tsutsumi, Hiroyuki ^{[1
]}

Suzuki, Nobuhiro ^{[1
]}

机构：

[1] Sapporo Med Univ, Dept Pediat, Sch Med, Chuo Ku, Sapporo, Hokkaido 0608543, Japan

来源：

PEDIATRIC BLOOD & CANCER | 2009年 / 53卷 / 02期

关键词：

acute immune thrombocytopenic purpura; infant; refractory; rituximab; ITP-STUDY-GROUP; CLINICAL-FEATURES; CHILDREN; EFFICACY; TRIAL;

D O I：

10.1002/pbc.22036

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Some infants with acute immune thrombocytopenic purpura (ITP) do not respond to first-line therapy, and Currently there is no consensus on therapy for these refractory cases. We describe a 12-week-old infant with acute ITP who was unresponsive to intravenous immunoglobulin and corticosteroid, and developed gastrointestinal bleeding. Several combination therapies were unsuccessful. After four closes of rituximab followed by intravenous immunoglobulin and corticosteroid, his platelet Counts gradually increased. Combined therapy which includes rituximab May be a promising treatment for severe acute refractory ITP. Pediatr Blood Cancer 2009;53:203-205. (C) 2009 Wiley-Liss, Inc.

引用

页码：203 / 205

页数：3

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