Raman/fluorescence dual-sensing and imaging of intracellular pH distribution

被引：36
作者：
Cao, Yue
Qian, Ruo-Can
Li, Da-Wei
Long, Yi-Tao [1 ]
机构：
[1] E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 99期
基金：
中国博士后科学基金;
关键词：
RAMAN; NANOPARTICLES; TELOMERASE; NETWORK; DNA;
D O I：
10.1039/c5cc07697h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Herein, a pH-sensitive probe has been designed based on DNA modified gold nanoparticles (AuNPs) for Raman/fluorescence dual-imaging of the intracellular pH distribution. In the acidic environment of cancer cells, the configuration change of DNA on the probe surface could turn "on'' Raman/fluorescence signals simultaneously.
引用
收藏
页码：17584 / 17587
页数：4
相关论文
共 16 条
[1]   Regulatory network motifs and hotspots of cancer genes in a mammalian cellular signalling network [J].
Awan, A. ;
Bari, H. ;
Yan, F. ;
Moksong, S. ;
Yang, S. ;
Chowdhury, S. ;
Cui, Q. ;
Yu, Z. ;
Purisima, E. O. ;
Wang, E. .
IET SYSTEMS BIOLOGY, 2007, 1 (05) :292-297
[2]   Nanoparticles with Raman spectroscopic fingerprints for DNA and RNA detection [J].
Cao, YWC ;
Jin, RC ;
Mirkin, CA .
SCIENCE, 2002, 297 (5586) :1536-1540
[3]   Identification of breast cancer patients based on human signaling network motifs [J].
Chen, Lina ;
Qu, Xiaoli ;
Cao, Mushui ;
Zhou, Yanyan ;
Li, Wan ;
Liang, Binhua ;
Li, Weiguo ;
He, Weiming ;
Feng, Chenchen ;
Jia, Xu ;
He, Yuehan .
SCIENTIFIC REPORTS, 2013, 3
[4]   Micro-competition system for Raman quantification of multiple glycans on intact cell surface [J].
Chen, Yunlong ;
Ding, Lin ;
Xu, Junqiang ;
Song, Wanyao ;
Yang, Min ;
Hu, Junjie ;
Ju, Huangxian .
CHEMICAL SCIENCE, 2015, 6 (07) :3769-3774
[5]   PREPARATION AND CHARACTERIZATION OF AU COLLOID MONOLAYERS [J].
GRABAR, KC ;
FREEMAN, RG ;
HOMMER, MB ;
NATAN, MJ .
ANALYTICAL CHEMISTRY, 1995, 67 (04) :735-743
[6]   Real-Time Molecular Imaging throughout the Entire Cell Cycle by Targeted Plasmonic-Enhanced Rayleigh/Raman Spectroscopy [J].
Kang, Bin ;
Austin, Lauren A. ;
El-Sayed, Mostafa A. .
NANO LETTERS, 2012, 12 (10) :5369-5375
[7]   Nanoparticle-based bio-bar codes for the ultrasensitive detection of proteins [J].
Nam, JM ;
Thaxton, CS ;
Mirkin, CA .
SCIENCE, 2003, 301 (5641) :1884-1886
[8]   Smart Vesicle Kit for In Situ Monitoring of Intracellular Telomerase Activity Using a Telomerase-Responsive Probe [J].
Qian, Ruocan ;
Ding, Lin ;
Yan, Liwen ;
Lin, Manfei ;
Ju, Huangxian .
ANALYTICAL CHEMISTRY, 2014, 86 (17) :8642-8648
[9]   A Robust Probe for Lighting Up Intracellular Telomerase via Primer Extension To Open a Nicked Molecular Beacon [J].
Qian, Ruocan ;
Ding, Lin ;
Yan, Liwen ;
Lin, Manfei ;
Ju, Huangxian .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2014, 136 (23) :8205-8208
[10]   Nanostructures in biodiagnostics [J].
Rosi, NL ;
Mirkin, CA .
CHEMICAL REVIEWS, 2005, 105 (04) :1547-1562
12