VanWyk-Grumbach syndrome in a male pediatric patient: A rare case report and literature review

被引：14
作者：
Zhang, Shanshan [1 ]
Yang, Jingyan [1 ]
Zheng, Rongxiu [1 ]
Jiang, Lihong [1 ]
Wei, Ying [1 ]
Liu, Geli [1 ]
机构：
[1] Tianjin Med Univ, Gen Hosp, Dept Pediat, 154 Anshan Rd, Tianjin 300052, Peoples R China
来源：
EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2017年 / 13卷 / 03期
关键词：
hypothyroidism; VanWyk-Grumbach syndrome; MULTIPLE OVARIAN CYSTS; PRECOCIOUS PUBERTY; PRIMARY HYPOTHYROIDISM; ACQUIRED HYPOTHYROIDISM; HORMONE; WYK; MECHANISM; GIRL;
D O I：
10.3892/etm.2017.4086
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Primary hypothyroidism usually leads to retardation of linear growth and delay or even arrest of puberty in juvenile patients. In rare cases, pediatric patients with hypothyroidism may present with signs of VanWyk-Grumbach's syndrome (VWGS), which includes juvenile hypothyroidism, delayed bone age and pseudoprecocious puberty. The present study reported on a rare case of VWGS and other complications, including obesity, short stature, hepatomegaly and pituitary hyperplasia. In addition, a comprehensive literature review was performed to illustrate the treatment and outcome of VWGS in pediatric patients. The present study contributed to the current knowledge regarding the diagnosis and treatment of VWGS in pediatric patients.
引用
收藏
页码：1151 / 1154
页数：4
相关论文
共 32 条
  • [1] A POTENTIAL NOVEL MECHANISM FOR PRECOCIOUS PUBERTY IN JUVENILE HYPOTHYROIDISM
    ANASTI, JN
    FLACK, MR
    FROEHLICH, J
    NELSON, LM
    NISULA, BC
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1995, 80 (01) : 276 - 279
  • [2] An unusual presentation of acquired hypothyroidism: the Van Wyk-Grumbach syndrome
    Baranowski, E.
    Hoegler, W.
    [J]. EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2012, 166 (03) : 537 - 542
  • [3] Van Wyk and Grumbach syndrome revisited: imaging and clinical findings in pre- and postpubertal girls
    Browne, Lorna P.
    Boswell, Hillary B.
    Crotty, Eric J.
    O'Hara, Sara M.
    Birkemeier, Krista L.
    Guillerman, R. Paul
    [J]. PEDIATRIC RADIOLOGY, 2008, 38 (05) : 538 - 542
  • [4] HYPOTHYROIDISM-INDUCED MACROORCHIDISM - USE OF A GONADOTROPIN-RELEASING-HORMONE AGONIST TO UNDERSTAND ITS MECHANISM AND AUGMENT ADULT STATURE
    BRUDER, JM
    SAMUELS, MH
    BREMNER, WJ
    RIDGWAY, EC
    WIERMAN, ME
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1995, 80 (01) : 11 - 16
  • [5] HYPOTHALAMIC-PITUITARY GONADAL AXIS IN BOYS WITH PRIMARY HYPOTHYROIDISM AND MACROORCHIDISM
    CASTROMAGANA, M
    ANGULO, M
    CANAS, A
    SHARP, A
    FUENTES, B
    [J]. JOURNAL OF PEDIATRICS, 1988, 112 (03) : 397 - 402
  • [6] Chattopadhyay A, 2003, J PEDIATR SURG, V38, P1390, DOI 10.1016/S0022-3468(03)00403-2
  • [7] ANEMIA IN CHILDREN AND ADOLESCENTS WITH HYPOTHYROIDISM
    CHU, JY
    MONTELEONE, JA
    PEDEN, VH
    GRAVISS, ER
    VERNAVA, AM
    [J]. CLINICAL PEDIATRICS, 1981, 20 (11) : 696 - 699
  • [8] Non-alcoholic fatty liver disease across the spectrum of hypothyroidism
    Chung, Goh Eun
    Kim, Donghee
    Kim, Won
    Yim, Jeong Yoon
    Park, Min Jung
    Kim, Yoon Jun
    Yoon, Jung-Hwan
    Lee, Hyo-Suk
    [J]. JOURNAL OF HEPATOLOGY, 2012, 57 (01) : 150 - 156
  • [9] Presence and absence of follicle-stimulating hormone receptor mutations provide some insights into spontaneous ovarian hyperstimulation syndrome physiopathology
    De Leener, A
    Montanelli, L
    Van Durme, J
    Chae, H
    Smits, G
    Vassart, G
    Costagliola, S
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (02) : 555 - 562
  • [10] Paracrinicity: The story of 30 years of cellular pituitary crosstalk
    Denef, C.
    [J]. JOURNAL OF NEUROENDOCRINOLOGY, 2008, 20 (01) : 1 - 70
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