Hemorrhagic Fever with Renal Syndrome: Pathogenesis and Clinical Picture

被引：168

作者：

Jiang, Hong ^{[1
]}

Du, Hong ^{[1
]}

Wang, Li M. ^{[2
]}

Wang, Ping Z. ^{[1
]}

Bai, Xue F. ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Tangdu Hosp, Ctr Infect Dis, Xian 710032, Peoples R China

[2] Fourth Mil Med Univ, Sch Basic Med, Dept Microbiol, Xian 710032, Peoples R China

来源：

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2016年 / 6卷

基金：

中国国家自然科学基金;

关键词：

hantavirus; hemorrhagic fever with renal syndrome; Bunyavirus; hantaan virus; pathogenesis; REGULATORY T-CELLS; HANTAVIRUS NUCLEOCAPSID PROTEINS; ENDOTHELIAL GROWTH-FACTOR; HANTAAN VIRUS-INFECTION; NECROSIS-FACTOR-ALPHA; ANDES VIRUS; RNA LOAD; NEPHROPATHIA-EPIDEMICA; GENETIC SUSCEPTIBILITY; IMMUNE-RESPONSE;

D O I：

10.3389/fcimb.2016.00001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Hantaan virus (HTNV) causes hemorrhagic fever with renal syndrome (HFRS), which is a zoonosis endemic in eastern Asia, especially in China. The reservoir host of HTNV is field mouse (Apodernus agraricus). The main manifestation of HFRS, including acute kidney injury, increases vascular permeability, and coagulation abnormalities. In this paper, we review the current knowledge of the pathogenesis of HFRS including virus factor, immunity factor and host genetic factors. Furthermore, the treatment and prevention will be discussed.

引用

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