Effects of As2O3 on DNA methylation, genomic instability, and LTR retrotransposon polymorphism in Zea mays

被引：16

作者：

Erturk, Filiz Aygun ^{[1
]}

Aydin, Murat ^{[2
]}

Sigmaz, Burcu ^{[1
]}

Taspinar, M. Sinan ^{[3
]}

Arslan, Esra ^{[1
]}

Agar, Guleray ^{[1
]}

Yagci, Semra ^{[1
]}

机构：

[1] Ataturk Univ, Fac Sci, Dept Biol, TR-25240 Erzurum, Turkey

[2] Ataturk Univ, Fac Agr, Dept Field Crops, TR-25240 Erzurum, Turkey

[3] Ataturk Univ, Fac Agr, Dept Agr Biotechnol, TR-25240 Erzurum, Turkey

来源：

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH | 2015年 / 22卷 / 23期

关键词：

As2O3; DNA methylation; LTR retrotransposons polymorphism; Genomic instability; Zea mays; INDUCED OXIDATIVE STRESS; SODIUM ARSENITE; IN-VITRO; EXPOSURE; TOXICITY; RESPONSES; PROMOTER; TOBACCO; DAMAGE; HYPERMETHYLATION;

D O I：

10.1007/s11356-015-5426-2

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Arsenic is a well-known toxic substance on the living organisms. However, limited efforts have been made to study its DNA methylation, genomic instability, and long terminal repeat (LTR) retrotransposon polymorphism causing properties in different crops. In the present study, effects of As2O3 (arsenic trioxide) on LTR retrotransposon polymorphism and DNA methylation as well as DNA damage in Zea mays seedlings were investigated. The results showed that all of arsenic doses caused a decreasing genomic template stability (GTS) and an increasing Random Amplified Polymorphic DNAs (RAPDs) profile changes (DNA damage). In addition, increasing DNA methylation and LTR retrotransposon polymorphism characterized a model to explain the epigenetically changes in the gene expression were also found. The results of this experiment have clearly shown that arsenic has epigenetic effect as well as its genotoxic effect. Especially, the increasing of polymorphism of some LTR retrotransposon under arsenic stress may be a part of the defense system against the stress.

引用

页码：18601 / 18606

页数：6

共 48 条

[1] Alzohairy AM, 2012, LIFE SCI J, V9, P5019
[2] Arsenic exposure is associated with decreased DNA repair in vitro and in individuals exposed to drinking water arsenic
Andrew, Angeline S.
Burgess, Jefferey L.
Meza, Maria M.
Demidenko, Eugene
Waugh, Mary G.
Hamilton, Joshua W.
Karagas, Margaret R.
[J]. ENVIRONMENTAL HEALTH PERSPECTIVES, 2006, 114 (08) : 1193 - 1198
[3] Zinc alleviates cadmium-induced oxidative stress in Ceratophyllum demersum L.:: a free floating freshwater macrophyte
Aravind, P
Prasad, MNV
[J]. PLANT PHYSIOLOGY AND BIOCHEMISTRY, 2003, 41 (04) : 391 - 397
[4] ATSDR, 2007, AG TOX SUBS IN PRESS, P30333
[5] Role of genomic instability in arsenic-induced carcinogenicity. A review
Bhattacharjee, Pritha
Banerjee, Mayukh
Giri, Ashok K.
[J]. ENVIRONMENT INTERNATIONAL, 2013, 53 : 29 - 40
[6] ARSENATE TOXICITY FOR WHEAT AND LETTUCE IN SIX CHINESE SOILS WITH DIFFERENT PROPERTIES
Cao, Qing
Hu, Qin-Hong
Baisch, Cristoph
Khan, Sardar
Zhu, Yong-Guan
[J]. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 2009, 28 (09) : 1946 - 1950
[7] Arsenic salts induced autophagic cell death and hypermethylation of DAPK promoter in SV-40 immortalized human uroepithelial cells
Chai, Chee-Yin
Huang, Ya-Chun
Hung, Wen-Chun
Kang, Wan-Yi
Chen, Wan-Tzu
[J]. TOXICOLOGY LETTERS, 2007, 173 (01) : 48 - 56
[8] Chen H, 2001, MOL CARCINOGEN, V30, P79, DOI 10.1002/1098-2744(200102)30:2<79::AID-MC1016>3.0.CO
[9] 2-F
[10] Quantitative mass spectrometry reveals the epigenome as a target of arsenic
Chu, Feixia
Ren, Xuefeng
Chasse, Amanda
Hickman, Taylor
Zhang, Luoping
Yuh, Jessica
Smith, Martyn T.
Burlingame, Alma L.
[J]. CHEMICO-BIOLOGICAL INTERACTIONS, 2011, 192 (1-2) : 113 - 117

← 1 2 3 4 5 →