Alcohol drinking and cutaneous melanoma risk: a systematic review and dose-risk meta-analysis

被引:50
作者
Rota, M. [1 ,3 ]
Pasquali, E. [2 ]
Bellocco, R. [2 ,4 ]
Bagnardi, V. [2 ,5 ]
Scotti, L. [2 ]
Islami, F. [6 ,7 ,8 ]
Negri, E. [3 ]
Boffetta, P. [6 ,7 ]
Pelucchi, C. [3 ]
Corrao, G. [2 ]
La Vecchia, C. [3 ,9 ]
机构
[1] Univ Milano Bicocca, Ctr Biostat Clin Epidemiol, Dept Hlth Sci, Milan, Italy
[2] Univ Milano Bicocca, Dept Stat & Quantitat Methods, Milan, Italy
[3] Ist Ric Farmacol Mario Negri, IRCCS, Dept Epidemiol, I-20156 Milan, Italy
[4] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
[5] European Inst Oncol, Div Epidemiol & Biostat, Milan, Italy
[6] Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY USA
[7] Icahn Sch Med Mt Sinai, Inst Translat Epidemiol, New York, NY USA
[8] Univ Tehran Med Sci, Digest Dis Res Inst, Digest Oncol Res Ctr, Tehran, Iran
[9] Univ Milan, Dept Clin Sci & Community Hlth, Milan, Italy
关键词
MALIGNANT-MELANOMA; CANCER INCIDENCE; DIET; CONSUMPTION; SMOKING; EXPOSURE; BIAS;
D O I
10.1111/bjd.12856
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
It has been suggested that alcohol intake increases sunburn severity, a major risk factor for cutaneous melanoma (CM). Several epidemiological studies have investigated the relationship between alcohol consumption and CM, but the evidence is inconsistent. Therefore, we aimed to quantify this relationship better, using a meta-analytical approach. The dose-risk relationship was also modelled through a class of flexible nonlinear meta-regression random effects models. The present meta-analysis included 16 studies (14 case-control and two cohort investigations) with a total of 6251 cases of CM. The pooled relative risk (RR) for any alcohol drinking compared with no/occasional drinking was 1.20 [95% confidence interval (CI) 1.06-1.37]. The risk estimate was similar in case-control (RR 1.20, 95% CI 1.01-1.44) and cohort studies (RR 1.26, 95% CI 1.19-1.35). The pooled RR was 1.10 (95% CI 0.96-1.26) for light alcohol drinking (<= 1 drink per day) and 1.18 (95% CI 1.01-1.40) for moderate-to-heavy drinking. The pooled RR from 10 studies adjusting for sun exposure was 1.15 (95% CI 0.94-1.41), while the RR from six unadjusted studies was 1.27 (95% CI 1.20-1.35). No evidence of publication bias was detected. This meta-analysis of published data reveals that alcohol consumption is positively associated with the risk of CM. However, caution in interpreting these results is required, as residual confounding by sun exposure cannot be ruled out.
引用
收藏
页码:1021 / 1028
页数:8
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