An operational definition of epigenetics

被引：1183

作者：

Berger, Shelley L. ^{[1
]}

Kouzarides, Tony ^{[2
,3
]}

Shiekhattar, Ramin ^{[4
]}

Shilatifard, Ali ^{[5
]}

机构：

[1] Univ Penn, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA

[2] Gurdon Inst, Cambridge CB2 1QN, England

[3] Dept Pathol, Cambridge CB2 1QN, England

[4] Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA

[5] Stowers Inst Med Res, Kansas City, MO 64110 USA

来源：

GENES & DEVELOPMENT | 2009年 / 23卷 / 07期

关键词：

Epigenetics; DNA methylation; noncoding RNA; histone modification; histone variant;

D O I：

10.1101/gad.1787609

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A recent meeting (December 2008) regarding chromatin-based epigenetics was hosted by the Banbury Conference Center and Cold Spring Harbor Laboratory. The intent was to discuss aspects of epigenetic control of genomic function, and to arrive at a consensus definition of "epigenetics'' to be considered by the broader community. It was evident that multiple mechanistic steps lead to the stable heritance of the epigenetic phenotype. Below we provide our view and interpretation of the proceedings at the meeting.

引用

页码：781 / 783

页数：3