共 33 条
Regulatory T cells suppress CD4+ T cells through NFAT-dependent transcriptional mechanisms
被引:39
作者:

Shin, Daniel S.
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机构:
Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10467 USA Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10467 USA

Jordan, Ayana
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机构:
Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10467 USA Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10467 USA

Basu, Samik
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h-index: 0
机构:
Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10467 USA Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10467 USA

Thomas, Rajan M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA USA
Childrens Hosp Philadelphia, Res Inst, Philadelphia, PA 19104 USA Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10467 USA

Bandyopadhyay, Sanmay
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h-index: 0
机构:
Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10467 USA Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10467 USA

de Zoeten, Edwin F.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA USA
Childrens Hosp Philadelphia, Res Inst, Philadelphia, PA 19104 USA Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10467 USA

Wells, Andrew D.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA USA
Childrens Hosp Philadelphia, Res Inst, Philadelphia, PA 19104 USA Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10467 USA

Macian, Fernando
论文数: 0 引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10467 USA Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10467 USA
机构:
[1] Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10467 USA
[2] Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA USA
[3] Childrens Hosp Philadelphia, Res Inst, Philadelphia, PA 19104 USA
基金:
美国国家卫生研究院;
关键词:
Ikaros;
NFAT;
regulatory T cell;
GENE-TRANSCRIPTION;
REPRESSOR ICER;
ANTIGEN;
4;
TOLERANCE;
INDUCTION;
INFLAMMATION;
ACETYLATION;
LYMPHOCYTES;
EXPRESSION;
FACILITATE;
D O I:
10.15252/embr.201338233
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Regulatory T cells (Tregs) control autoreactive T cells by inhibiting activation-induced proliferation and cytokine expression. The molecular mechanisms responsible for the inactivation of effector T cells by Tregs remain yet to be fully characterized. We report that T-helper cells stimulated in the presence of Tregs quickly activate NFAT1 and have increased NFAT1-dependent expression of the transcription repressor Ikaros. NFAT1 deficiency or dominant-negative Ikaros compromises Treg-mediated inhibition of T-helper cells in vitro and in vivo. Thus, our results place NFAT-dependent mechanisms as general regulators of T-cell tolerance and show that Treg-mediated suppression of T-helper cells results from the activation of NFAT-regulated gene expression.
引用
收藏
页码:991 / 999
页数:9
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