A novel and practical asymmetric synthesis of dapoxetine hydrochloride

被引：7
|
作者：
Zhu, Yijun [1 ,2 ]
Liu, Zhenren [1 ]
Li, Hongyan [1 ]
Ye, Deyong [2 ]
Zhou, Weicheng [1 ]
机构：
[1] State Inst Pharmaceut Ind, Shanghai Key Lab Anti Infect, State Key Lab New Drug & Pharmaceut Proc, Shanghai 201203, Peoples R China
[2] Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China
来源：
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 11卷
关键词：
asymmetric synthesis; dapoxetine hydrochloride; stereoselectivity; (S)-tert-butanesulfinamide; PREMATURE EJACULATION; (S)-DAPOXETINE;
D O I：
10.3762/bjoc.11.283
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel and practical asymmetric synthesis of dapoxetine hydrochloride by using the chiral auxiliary (S)-tert-butanesulfinamide was explored. The synthesis was concise, mild, and easy to perform. The overall yield and stereoselectivity were excellent.
引用
收藏
页码：2641 / 2645
页数：5
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