Mechanism-based profiling of enzyme families

被引：466
作者：
Evans, Michael J.
Cravatt, Benjamin F. [1 ]
机构：
[1] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
[3] Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA
来源：
CHEMICAL REVIEWS | 2006年 / 106卷 / 08期
关键词：
D O I：
10.1021/cr050288g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The literature includes a number of studies expanding the technological scope and biological applications of activity-based protein profiling (ABPP). This review covers these advances and present their findings within the prevailing themes that have been served as the foundation for ABPP. Focus is on the explanation of ABP design to highlight how the structure and reactivity of these reagents influences their target portfolio and the scope of ABPP experiments. The review is presented into sections: (1) the design of ABPs for functional proteomics, (2) biological applications of ABPs, (3) methodological advances beyond the central paradigm and (4) ABPs and their application beyond comparative proteomics.
引用
收藏
页码：3279 / 3301
页数：23
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