Antispasmodic Effect of Essential Oils and Their Constituents: A Review

被引：55

作者：

Heghes, Simona Codruta ^{[1
]}

Vostinaru, Oliviu ^{[2
]}

Rus, Lucia Maria ^{[1
]}

Mogosan, Cristina ^{[2
]}

Iuga, Cristina Adela ^{[1
,3
]}

Filip, Lorena ^{[4
]}

机构：

[1] Iuliu Hatieganu Univ Med & Pharm, Dept Drug Anal, Cluj Napoca 400349, Romania

[2] Iuliu Hatieganu Univ Med & Pharm, Dept Pharmacol Physiol & Physiopathol, Cluj Napoca 400349, Romania

[3] Iuliu Hatieganu Univ Med & Pharm, Dept Prote & Metabol, MedFuture Res Ctr Adv Med, Cluj Napoca 400349, Romania

[4] Iuliu Hatieganu Univ Med & Pharm, Dept Bromatol, Hyg, Nutr, Cluj Napoca 400349, Romania

来源：

MOLECULES | 2019年 / 24卷 / 09期

关键词：

essential oils; aromatic plants; antispasmodic effect; isolated ileum; monoterpenes; IRRITABLE-BOWEL-SYNDROME; ARTEMISIA-DRACUNCULUS L; MENTHA-X-VILLOSA; YLANG ESSENTIAL OIL; ALBA ESSENTIAL OIL; CHEMICAL-COMPOSITION; PEPPERMINT-OIL; SMOOTH-MUSCLE; SPASMOLYTIC ACTIVITY; ANTIMICROBIAL ACTIVITY;

D O I：

10.3390/molecules24091675

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The antispasmodic effect of drugs is used for the symptomatic treatment of cramping and discomfort affecting smooth muscles from the gastrointestinal, billiary or genitourinary tract in a variety of clinical situations.The existing synthetic antispasmodic drugs may cause a series of unpleasant side effects, and therefore the discovery of new molecules of natural origin is an important goal for the pharmaceutical industry. This review describes a series of recent studies investigating the antispasmodic effect of essential oils from 39 plant species belonging to 12 families. The pharmacological models used in the studies together with the mechanistic discussions and the chemical composition of the essential oils are also detailed. The data clearly demonstrate the antispasmodic effect of the essential oils from the aromatic plant species studied. Further research is needed in order to ascertain the therapeutic importance of these findings.

引用

页数：29

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