IncRNAs: novel players in intervertebral disc degeneration and osteoarthritis

被引：113

作者：

Chen, Wen-Kang ^{[1
]}

Yu, Xiao-Hua ^{[2
]}

Yang, Wei ^{[3
]}

Wang, Cheng ^{[1
]}

He, Wen-Si ^{[1
]}

Yan, Yi-Guo ^{[1
]}

Zhang, Jian ^{[3
]}

Wang, Wen-Jun ^{[1
]}

机构：

[1] Univ South China, Affiliated Hosp 1, Dept Spine Surg, Hengyang, Hunan, Peoples R China

[2] Univ South China, Med Res Ctr, Hengyang, Hunan, Peoples R China

[3] Univ South China, Affiliated Hosp 1, Dept Hand & Microsurg, Hengyang, Hunan, Peoples R China

来源：

CELL PROLIFERATION | 2017年 / 50卷 / 01期

基金：

中国国家自然科学基金;

关键词：

LONG NONCODING RNA; ANNULUS FIBROSUS CELLS; OSTEOCHONDRAL JUNCTION; CHONDROCYTE APOPTOSIS; MOLECULAR-MECHANISMS; KNEE OSTEOARTHRITIS; HOTAIR EXPRESSION; PROSTATE-CANCER; GENE-EXPRESSION; POOR-PROGNOSIS;

D O I：

10.1111/cpr.12313

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The term long non-coding RNA (lncRNA) refers to a group of RNAs with length more than 200 nucleotides, limited protein-coding potential, and having widespread biological functions, including regulation of transcriptional patterns and protein activity, formation of endogenous small interfering RNAs (siRNAs) and natural microRNA (miRNA) sponges. Intervertebral disc degeneration (IDD) and osteoarthritis (OA) are the most common chronic, prevalent and age-related degenerative musculoskeletal disorders. Numbers of lncRNAs are differentially expressed in human degenerative nucleus pulposus tissue and OA cartilage. Moreover, some lncRNAs have been shown to be involved in multiple pathological processes during OA, including extracellular matrix (ECM) degradation, inflammatory responses, apoptosis and angiogenesis. In this-review, we summarize current knowledge concerning lncRNAs, from their biogenesis,classification and biological functions to molecular mechanisms and therapeutic potential in IDD and OA.

引用

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