Population homogeneity for the antibody response to COVID-19 BNT162b2/Comirnaty vaccine is only reached after the second dose across all adult age ranges

被引：20

作者：

Faro-Viana, Joao ^{[1
]}

Bergman, Marie-Louise ^{[2
]}

Goncalves, Ligia A. ^{[2
]}

Duarte, Nadia ^{[2
]}

Coutinho, Teresa P. ^{[3
]}

Borges, Patricia C. ^{[2
]}

Diwo, Christian ^{[2
]}

Castro, Rute ^{[4
]}

Matoso, Paula ^{[2
]}

Malheiro, Vanessa ^{[2
]}

Brennand, Ana ^{[2
]}

Kosack, Lindsay ^{[2
]}

Akpogheneta, Onome ^{[2
]}

Figueira, Joao M. ^{[1
]}

Cardoso, Conceicao ^{[1
]}

Casaca, Ana M. ^{[1
]}

Alves, Paula M. ^{[4
,5
]}

Nunes, Telmo ^{[3
]}

Penha-Goncalves, Carlos ^{[2
]}

Demengeot, Jocelyne ^{[2
]}

机构：

[1] Ctr Hosp Lisboa Ocidental, Serv Patol Clin, P-1449005 Lisbon, Portugal

[2] IGC, P-2780156 Oeiras, Portugal

[3] Univ Lisbon, Ctr Interdisciplinary Res Anim Hlth, CIISA, Fac Vet Med, P-1300477 Lisbon, Portugal

[4] IBET, P-2780901 Oeiras, Portugal

[5] Univ Nova Lisboa, Inst Tecnol Quim Biol Antonio Xavier, ITQB NOVA, P-2780157 Oeiras, Portugal

来源：

NATURE COMMUNICATIONS | 2022年 / 13卷 / 01期

关键词：

BNT162B2; VACCINE;

D O I：

10.1038/s41467-021-27761-z

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

While mRNA vaccines are administrated worldwide in an effort to contain the COVID-19 pandemic, the heterogeneity of the humoral immune response they induce at the population scale remains unclear. Here, in a prospective, longitudinal, cohort-study, including 1245 hospital care workers and 146 nursing home residents scheduled for BNT162b2 vaccination, together covering adult ages from 19 to 99 years, we analyse seroconversion to SARS-CoV-2 spike protein and amount of spike-specific IgG, IgM and IgA before vaccination, and 3-5 weeks after each dose. We show that immunogenicity after a single vaccine dose is biased to IgG, heterogeneous and reduced with increasing age. The second vaccine dose normalizes IgG seroconversion in all age strata. These findings indicate two dose mRNA vaccines is required to reach population scale humoral immunity. The results advocate for the interval between the two doses not to be extended, and for serological monitoring of elderly and immunosuppressed vaccinees.

引用

页数：8

共 30 条

[1] Signatures in SARS-CoV-2 spike protein conferring escape to neutralizing antibodies [J].

Alenquer, Marta ;

Ferreira, Filipe ;

Lousa, Diana ;

Valerio, Mariana ;

Medina-Lopes, Monica ;

Bergman, Marie-Louise ;

Goncalves, Juliana ;

Demengeot, Jocelyne ;

Leite, Ricardo B. ;

Lilue, Jingtao ;

Ning, Zemin ;

Penha-Goncalves, Carlos ;

Soares, Helena ;

Soares, Claudio M. ;

Amorim, Maria Joao .

PLOS PATHOGENS, 2021, 17 (08)

[2]

Amanat F, 2020, NAT MED, V26, P1033, DOI [10.1038/s41591-020-0913-5, 10.1101/2020.03.17.20037713]

[3] Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults [J].

Anderson, E. J. ;

Rouphael, N. G. ;

Widge, A. T. ;

Jackson, L. A. ;

Roberts, P. C. ;

Makhene, M. ;

Chappell, J. D. ;

Denison, M. R. ;

Stevens, L. J. ;

Pruijssers, A. J. ;

McDermott, A. B. ;

Flach, B. ;

Lin, B. C. ;

Doria-Rose, N. A. ;

O'Dell, S. ;

Schmidt, S. D. ;

Corbett, K. S. ;

Swanson, P. A., II ;

Padilla, M. ;

Neuzil, K. M. ;

Bennett, H. ;

Leav, B. ;

Makowski, M. ;

Albert, J. ;

Cross, K. ;

Edara, V. V. ;

Floyd, K. ;

Suthar, M. S. ;

Martinez, D. R. ;

Baric, R. ;

Buchanan, W. ;

Luke, C. J. ;

Phadke, V. K. ;

Rostad, C. A. ;

Ledgerwood, J. E. ;

Graham, B. S. ;

Beigel, J. H. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (25) :2427-2438

[4] SARS-CoV-2 Antibody Response in Persons with Past Natural Infection [J].

Anichini, Gabriele ;

Terrosi, Chiara ;

Gandolfo, Claudia ;

Gori Savellini, Gianni ;

Fabrizi, Simonetta ;

Miceli, Giovanni B. ;

Cusi, M. Grazia .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (01) :90-92

[5] BNT162b2 vaccine uptake and effectiveness in UK healthcare workers - a single centre cohort study [J].

Azamgarhi, Tariq ;

Hodgkinson, Michelle ;

Shah, Ashik ;

Skinner, John A. ;

Hauptmannova, Iva ;

Briggs, Tim W. R. ;

Warren, Simon .

NATURE COMMUNICATIONS, 2021, 12 (01)

[6] Vaccination in the elderly: The challenge of immune changes with aging [J].

Ciabattini, Annalisa ;

Nardini, Christine ;

Santoro, Francesco ;

Garagnani, Paolo ;

Franceschi, Claudio ;

Medaglini, Donata .

SEMINARS IN IMMUNOLOGY, 2018, 40 (0C) :83-94

[7] Antibody Persistence through 6 Months after the Second Dose of mRNA-1273 Vaccine for Covid-19 [J].

Doria-Rose, Nicole ;

Suthar, Mehul S. ;

Makowski, Mat .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (23) :2259-2261

[8] Antibody responses to the BNT162b2 mRNA vaccine in individuals previously infected with SARS-CoV-2 [J].

Ebinger, Joseph E. ;

Fert-Bober, Justyna ;

Printsev, Ignat ;

Wu, Min ;

Sun, Nancy ;

Prostko, John C. ;

Frias, Edwin C. ;

Stewart, James L. ;

Van Eyk, Jennifer E. ;

Braun, Jonathan G. ;

Cheng, Susan ;

Sobhani, Kimia .

NATURE MEDICINE, 2021, 27 (06) :981-+

[9]

Gilbert PB., 2021, medRxiv, DOI [DOI 10.1101/2021.08.09.21261290V4, DOI 10.1101/2021.08.09.21261290]

[10] Distinct antibody and memory B cell responses in SARS-CoV-2 naive and recovered individuals after mRNA vaccination [J].

Goel, Rishi R. ;

Apostolidis, Sokratis A. ;

Painter, Mark M. ;

Mathew, Divij ;

Pattekar, Ajinkya ;

Kuthuru, Oliva ;

Gouma, Sigrid ;

Hicks, Philip ;

Meng, Wenzhao ;

Rosenfeld, Aaron M. ;

Dysinger, Sarah ;

Lundgreen, Kendall A. ;

Kuri-Cervantes, Leticia ;

Adamski, Sharon ;

Hicks, Amanda ;

Korte, Scott ;

Oldridge, Derek A. ;

Baxter, Amy E. ;

Giles, Josephine R. ;

Weirick, Madison E. ;

McAllister, Christopher M. ;

Dougherty, Jeanette ;

Long, Sherea ;

D'Andrea, Kurt ;

Hamilton, Jacob T. ;

Betts, Michael R. ;

Prak, Eline T. Luning ;

Bates, Paul ;

Hensley, Scott E. ;

Greenplate, Allison R. ;

Wherry, E. John .

SCIENCE IMMUNOLOGY, 2021, 6 (58) :1-19

← 1 2 3 →