Pterocephanoside A, a new iridoid from a traditional Tibetan medicine, Pterocephalus hookeri

被引：9

作者：

Wang, Wen-Xiang ^{[1
]}

Luo, Shi-Ying ^{[2
]}

Wang, Yi ^{[3
]}

Xiang, Li ^{[2
]}

Liu, Xiu-Hua ^{[4
]}

Tang, Ce ^{[2
]}

Zhang, Yi ^{[3
]}

机构：

[1] Chengdu Univ Tradit Chinese Med, Sch Pharm, Dept Tradit Chinese Med Chem, Chengdu 611137, Peoples R China

[2] Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Chengdu 611137, Peoples R China

[3] Chengdu Univ Tradit Chinese Med, Ethn Med Acad Heritage Innovat Res Ctr, Chengdu 611137, Peoples R China

[4] Chengdu Univ Tradit Chinese Med, Sch Basic Med Sci, Dept Internal Class, 1166 Liutai Ave, Chengdu 611137, Sichuan, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2021年 / 23卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Dispsacaceae; pterocephanoside A; traditional Tibetan medicine; Pterocephalus hookeri; iridoid glycoside; anti-inflammatory activity; GLUCOSIDES;

D O I：

10.1080/10286020.2020.1860951

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

This work obtained and identified pterocephanoside A (1), one new iridoid glucoside derivative with rare structure of three iridoid glycosides linked to cyclopenta[c]pyran-3(1H)-one, and 10 known iridoids (2-11) from Pterocephalus hookeri through silica gel column chromatography and semi-preparative HPLC. The structure of the new compound was confirmed by 1D and 2D NMR and HRMS data analysis. Compounds 1 and 2 were isolated from this plant for the first time. The iridoids mostly possessed seco-iridoid subtype and iridoid subtype skeletons from P. hookeri. Compounds 1, 3, 4, and 6-11 showed weak anti-inflammatory activity.

引用

页码：1189 / 1196

页数：8

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