Promising therapeutic role of miR-27b in tumor

被引：29

作者：

Ding, Li ^{[1
,2
]}

Ni, Jie ^{[2
,3
]}

Yang, Fan ^{[2
]}

Huang, Lingli ^{[2
]}

Deng, Heng ^{[4
]}

Wu, Yang ^{[2
]}

Ding, Xuansheng ^{[1
]}

Tang, Jinhai ^{[2
,5
]}

机构：

[1] China Pharmaceut Univ, Sch Basic Med & Clin Pharm, Nanjing, Jiangsu, Peoples R China

[2] Nanjing Med Univ, Jiangsu Canc Hosp, Nanjing, Jiangsu, Peoples R China

[3] Nanjing Med Univ, Sch Clin Med 4, Nanjing, Jiangsu, Peoples R China

[4] AnHui Univ Tradit Chinese Med, Grad Sch, Hefei, Peoples R China

[5] Nanjing Med Univ, Affiliated Hosp 1, Dept Gen Surg, Nanjing 210029, Jiangsu, Peoples R China

来源：

TUMOR BIOLOGY | 2017年 / 39卷 / 03期

基金：

中国国家自然科学基金; 国家高技术研究发展计划(863计划);

关键词：

MicroRNA; microRNA-27b; cancer; therapy; biomarker; MICRORNA EXPRESSION; GROWTH-FACTOR; COLORECTAL-CANCER; UP-REGULATION; ANGIOGENESIS INHIBITOR; MULTIDRUG-RESISTANCE; MYELOID-LEUKEMIA; CARCINOMA CELLS; PROGRESSION; GENE;

D O I：

10.1177/1010428317691657

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MicroRNAs are small nonprotein-encoding RNAs ranging from 18 to 25 nucleotides in size and regulate multiple biological pathways via directly targeting a variety of associated genes in cancers. MicroRNA-27b is a highly conserved MicroRNA throughout vertebrates and there are two homologs (hsa-miR-27a and hsa-miR-27b) in humans. MicroRNA-27b is an intragenic microRNA located on chromosome 9q22.1 within the C9orf3 gene, clustering with miR-23b and miR-24-1 in human. As a frequently dysregulated microRNA in human cancers, microRNA-27b could function as a tumor suppressor or an oncogenic microRNA. More and more studies indicate that microRNA-27b is involved in affecting various biological processes, such as angiogenesis, proliferation, metastasis, and drug resistance, and thus may act as a promising therapeutic target in human cancers. In this review, we discuss the role of microRNA-27b in detail and offer novel insights into molecular targeting therapy for cancers.

引用

页数：13

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