Use of Interleukin-1 Blockers in Pericardial and Cardiovascular Diseases

被引：31

作者：

Emmi, Giacomo ^{[1
]}

Urban, Maria Letizia ^{[2
]}

Imazio, Massimo ^{[3
]}

Gattorno, Marco ^{[4
]}

Maestroni, Silvia ^{[5
]}

Lopalco, Giuseppe ^{[6
]}

Cantarini, Luca ^{[7
,8
]}

Prisco, Domenico ^{[1
]}

Brucato, Antonio ^{[5
]}

机构：

[1] Univ Firenze, Dept Expt & Clin Med, Largo Brambilla 3, I-50134 Florence, Italy

[2] Univ Hosp Parma, Nephrol Unit, Parma, Italy

[3] AOU Citta Salute & Sci Torino, Cardiovasc & Thorac Dept, Univ Cardiol, Turin, Italy

[4] G Gaslini Inst Children, Unit Autoinflammatory Dis & Immunodeficiencies, Clin Pediat & Rheumatol, Genoa, Italy

[5] Osped Papa Giovanni XXIII, Internal Med, Bergamo, Italy

[6] Dept Emergency & Organ Transplantat, Rheumatol Unit, Bari, Italy

[7] Univ Siena, Res Ctr Syst Autoinflammatory Dis, Behcets Dis Clin, Siena, Italy

[8] Univ Siena, Rheumatol Ophthalmol Collaborat Uveitis Ctr, Siena, Italy

来源：

CURRENT CARDIOLOGY REPORTS | 2018年 / 20卷 / 08期

关键词：

Interleukin-1; Anakinra; Canakinumab; Pericarditis; Atherosclerosis; Cardiovascular disease; ACUTE MYOCARDIAL-INFARCTION; IDIOPATHIC RECURRENT PERICARDITIS; RECEPTOR ANTAGONIST ANAKINRA; C-REACTIVE PROTEIN; LONG-TERM EFFICACY; CONSTRICTIVE PERICARDITIS; NLRP3; INFLAMMASOME; HEART-FAILURE; BEHCETS-DISEASE; SAFETY PROFILE;

D O I：

10.1007/s11886-018-1007-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of Review This review aims to summarize the role of the interleukin-1 (IL-1) blocking agents in cardiovascular diseases, briefly describing the pathogenetic rationale and the most relevant clinical studies. Recent Findings IL-1 is a pivotal cytokine of the innate immune system. Anti-IL-1 agents are currently used for the treatment of several autoimmune and autoinflammatory conditions. Recently, the role of IL-1 has also emerged in cardiovascular diseases. Indeed, two recent randomized controlled trials have shown that the IL-1 receptor antagonist anakinra is effective for the treatment of idiopathic recurrent pericarditis and the IL-1 beta blocking agent canakinumab is effective in reducing myocardial infarction in people at risk. Interestingly, interfering with IL-1 has proved to be also effective in other cardiovascular manifestations, such as myocarditis, arrhythmias, and heart failure. Summary Blocking the IL-1 pathway is a possible new therapeutic strategy, potentially leading to innovative therapies in many acute and chronic cardiovascular diseases.

引用

页数：12

共 68 条

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