A ROMPGEL-supported N-hydroxysuccinimide:: A host of acylations with minimal purification

被引：45

作者：

Barrett, AGM ^{[1
]}

Cramp, SM

Roberts, RS

Zecri, FJ

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AY, England

[2] Rhone Poulenc Agr Ltd, Ongar CM5 0HW, Essex, England

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 03期

关键词：

D O I：

10.1021/ol991208w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A novel N-hydroxysuccinimide ring-opening metathesis polymer is described as a recyclable supported acyl transfer reagent. Amides, carbamates, ureas, Weinreb amides, and hydroxamic acids are all obtained in excellent yields and purities from amines with minimal purification.

引用

页码：261 / 264

页数：4

共 45 条

[1] Resin-supported labeling reagents [J].

Adamczyk, M ;

Fishpaugh, JR ;

Mattingly, PG .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (02) :217-220

[2] Preparation and use of N-hydroxysuccinimidyl active ester resins [J].

Adamczyk, M ;

Fishpaugh, JR ;

Mattingly, PG .

TETRAHEDRON LETTERS, 1999, 40 (03) :463-466

[3] SYNTHESES AND REACTIONS OF FUNCTIONAL POLYMERS .42. PREPARATION AND USE OF POLYMERS HAVING N-HYDROXY-SUCCINIMIDE UNIT IN CHAIN [J].

AKIYAMA, M ;

NARITA, M ;

OKAWARA, M .

JOURNAL OF POLYMER SCIENCE PART A-1-POLYMER CHEMISTRY, 1969, 7 (5PA1) :1299-&

[4] SYNTHESES AND REACTIONS OF FUNCTIONAL POLYMERS .46. PREPARATION AND REACTIONS OF N-BENZYLOXYISOMALEIMIDE-STYRENE COPOLYMER [J].

AKIYAMA, M ;

YANAGISA.Y ;

OKAWARA, M .

JOURNAL OF POLYMER SCIENCE PART A-1-POLYMER CHEMISTRY, 1969, 7 (7PA1) :1905-&

[5]

AKIYAMA M, 1976, TETRAHEDRON LETT, P1015

[6] USE OF RESINS CONTAINING MIXED SULFONIC-ACETIC ANHYDRIDES AS ACYLATING AGENTS [J].

ANG, TL ;

HARWOOD, HJ .

JOURNAL OF MACROMOLECULAR SCIENCE-CHEMISTRY, 1973, A 7 (05) :1079-1083

[7] Multi-valent polymer of vancomycin: enhanced antibacterial activity against VRE [J].

Arimoto, H ;

Nishimura, K ;

Kinumi, T ;

Hayakawa, I ;

Uemura, D .

CHEMICAL COMMUNICATIONS, 1999, (15) :1361-1362

[8] Horner-Emmons synthesis with minimal purification using ROMPGEL: A novel high-loading matrix for supported reagents [J].

Barrett, AGM ;

Cramp, SM ;

Roberts, RS ;

Zecri, FJ .

ORGANIC LETTERS, 1999, 1 (04) :579-582

[9] ROMP-spheres: A novel high-loading polymer support using cross metathesis between vinyl polystyrene and norbornene derivatives [J].

Barrett, AGM ;

Cramp, SM ;

Roberts, RS .

ORGANIC LETTERS, 1999, 1 (07) :1083-1086

[10] Synthesis of catalytically active polymers by means of ROMP:: An effective approach toward polymeric homogeneously soluble catalysts [J].

Bolm, C ;

Dinter, CL ;

Seger, A ;

Höcker, H ;

Brozio, J .

JOURNAL OF ORGANIC CHEMISTRY, 1999, 64 (16) :5730-5731

← 1 2 3 4 5 →