Clinical Correlations between Treatment with Anticoagulants/Antiaggregants and Late Rectal Toxicity after Radiotherapy for Prostate Cancer

被引：1
作者：
Takeda, Ken [1 ]
Ogawa, Yoshihiro [1 ]
Ariga, Hisanori [1 ]
Koto, Masashi [1 ]
Sakayauchi, Toru [1 ]
Fujimoto, Keisuke [1 ]
Narazaki, Kakutaro [1 ]
Mitsuya, Masatoshi [1 ]
Takai, Yoshihiro [2 ]
Yamada, Shogo [1 ]
机构：
[1] Tohoku Univ, Sch Med, Dept Radiat Oncol, Aoba Ku, Sendaishi 9808574, Japan
[2] Tohoku Univ, Sch Med, Dept Radiol Sci, Aoba Ku, Sendaishi 9808574, Japan
来源：
ANTICANCER RESEARCH | 2009年 / 29卷 / 05期
关键词：
Prostate cancer; radiotherapy; late toxicity; rectal toxicity; EXTERNAL-BEAM IRRADIATION; TERM TREATMENT SEQUELAE; CONFORMAL RADIOTHERAPY; ADENOCARCINOMA; MULTICENTER; PREDICTORS; CARCINOMA; 3D-CRT; RTOG;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim: To assess variables related to grade 2 or higher late rectal toxicity (LRT) in prostate cancer treated with external radiotherapy. Patients and Methods: A retrospective analysis was carried out of 232 patients with T1-T3 prostate cancer treated with 3-dimensional conformal radiotherapy (3DCRT) (106 patients) or intensity modulated radiotherapy (IMRT) (126 patients) between June 2000 and May 2007. One hundred and seventy-seven patients received androgen deprivation therapy (ADT);fifty patients used anticoagulants/antiaggregants for vascular disease. Results: The median follow-up was 31 months (range, 6-79). At 5 years, the cumulative incidence of grade 2 or 3 LRT was 5.6%. On multivariate analysis, medication with anticoagulants/antiaggregants was correlated with grade 2 or 3 LRT (p=0.027), whereas age, National Comprehensive Cancer Network risk group classification, use of ADT, radiotherapy technique (3DCRT vs. IMRT) and total irradiated dose were not. Conclusion: Treatment with anticoagulants/antiaggregants appears to be a factor in grade 2 or 3 LRT.
引用
收藏
页码：1831 / 1834
页数：4
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