Clinical Correlations between Treatment with Anticoagulants/Antiaggregants and Late Rectal Toxicity after Radiotherapy for Prostate Cancer

被引：1

作者：

Takeda, Ken ^{[1
]}

Ogawa, Yoshihiro ^{[1
]}

Ariga, Hisanori ^{[1
]}

Koto, Masashi ^{[1
]}

Sakayauchi, Toru ^{[1
]}

Fujimoto, Keisuke ^{[1
]}

Narazaki, Kakutaro ^{[1
]}

Mitsuya, Masatoshi ^{[1
]}

Takai, Yoshihiro ^{[2
]}

Yamada, Shogo ^{[1
]}

机构：

[1] Tohoku Univ, Sch Med, Dept Radiat Oncol, Aoba Ku, Sendaishi 9808574, Japan

[2] Tohoku Univ, Sch Med, Dept Radiol Sci, Aoba Ku, Sendaishi 9808574, Japan

来源：

ANTICANCER RESEARCH | 2009年 / 29卷 / 05期

关键词：

Prostate cancer; radiotherapy; late toxicity; rectal toxicity; EXTERNAL-BEAM IRRADIATION; TERM TREATMENT SEQUELAE; CONFORMAL RADIOTHERAPY; ADENOCARCINOMA; MULTICENTER; PREDICTORS; CARCINOMA; 3D-CRT; RTOG;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: To assess variables related to grade 2 or higher late rectal toxicity (LRT) in prostate cancer treated with external radiotherapy. Patients and Methods: A retrospective analysis was carried out of 232 patients with T1-T3 prostate cancer treated with 3-dimensional conformal radiotherapy (3DCRT) (106 patients) or intensity modulated radiotherapy (IMRT) (126 patients) between June 2000 and May 2007. One hundred and seventy-seven patients received androgen deprivation therapy (ADT);fifty patients used anticoagulants/antiaggregants for vascular disease. Results: The median follow-up was 31 months (range, 6-79). At 5 years, the cumulative incidence of grade 2 or 3 LRT was 5.6%. On multivariate analysis, medication with anticoagulants/antiaggregants was correlated with grade 2 or 3 LRT (p=0.027), whereas age, National Comprehensive Cancer Network risk group classification, use of ADT, radiotherapy technique (3DCRT vs. IMRT) and total irradiated dose were not. Conclusion: Treatment with anticoagulants/antiaggregants appears to be a factor in grade 2 or 3 LRT.

引用

页码：1831 / 1834

页数：4

共 50 条

[31] Nomogram to predict rectal toxicity following prostate cancer radiotherapy [J].

Delobel, Jean-Bernard ;

Gnep, Khemara ;

David Ospina, Juan ;

Beckendorf, Veronique ;

Chira, Ciprian ;

Zhu, Jian ;

Bossi, Alberto ;

Messai, Taha ;

Acosta, Oscar ;

Castelli, Joel ;

de Crevoisier, Renaud .

PLOS ONE, 2017, 12 (06)

[32] Acute and Late Rectal Toxicity Following Hypofractionated Radiotherapy in Patients With Prostate Cancer: Results of a Prospective Study [J].

Kounadis, Georgios ;

Syrigos, Nikolaos ;

Kougioumtzopoulou, Andromachi ;

Bamias, Georgios ;

Kotteas, Ilias ;

Papatheodoridis, Georgios ;

Grapsa, Dimitra .

IN VIVO, 2022, 36 (04) :1875-1880

[33] Influence of rectal volume changes during radiotherapy for prostate cancer:: A predictive model for mild-tomoderate late rectal toxicity [J].

Miralbell, R ;

Taussky, D ;

Rinaldi, O ;

Lomax, A ;

Canales, S ;

Escude, L ;

Nouet, P ;

Özsoy, O ;

Rouzaud, M .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2003, 57 (05) :1280-1284

[34] Predictive Factors of Late-onset Rectal Mucosal Changes After Radiotherapy of Prostate Cancer [J].

Ippolito, Edy ;

Guido, Alessandra ;

Macchia, Gabriella ;

Deodato, Francesco ;

Giaccherini, Lucia ;

Farioli, Andrea ;

Arcelli, Alessandra ;

Cuicchi, Dajana ;

Frazzoni, Leonardo ;

Cilla, Savino ;

Buwenge, Milly ;

Mantini, Giovanna ;

Alitto, Anna R. ;

Nuzzo, Marianna ;

Valentini, Vincenzo ;

Ingrosso, Marcello ;

Morganti, Alessio G. ;

Fuccio, Lorenzo .

IN VIVO, 2017, 31 (05) :961-966

[35] Dose-volume response analyses of late rectal bleeding after radiotherapy for prostate cancer [J].

Tucker, SL ;

Cheung, R ;

Dong, L ;

Liu, HH ;

Thames, HD ;

Huang, EH ;

Kuban, D ;

Mohan, R .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2004, 59 (02) :353-365

[36] Relationships between bladder dose-volume/surface histograms and acute urinary toxicity after radiotherapy for prostate cancer [J].

Carillo, Viviana ;

Cozzarini, Cesare ;

Rancati, Tiziana ;

Avuzzi, Barbara ;

Botti, Andrea ;

Borca, Valeria Casanova ;

Cattari, Gabriella ;

Civardi, Francesco ;

Esposti, Claudio Degli ;

Franco, Pierfrancesco ;

Girelli, Giuseppe ;

Maggio, Angelo ;

Muraglia, Alessandro ;

Palombarini, Marcella ;

Pierelli, Alessio ;

Pignoli, Emanuele ;

Vavassori, Vittorio ;

Zeverino, Michele ;

Valdagni, Riccardo ;

Fiorino, Claudio .

RADIOTHERAPY AND ONCOLOGY, 2014, 111 (01) :100-105

[37] Brachytherapy for the treatment of recurrent prostate cancer after radiotherapy or radical prostatectomy [J].

Gomez-Veiga, Francisco ;

Marino, Alfonso ;

Alvarez, Luis ;

Rodriguez, Ignacio ;

Fernandez, Carlos ;

Pertega, Sonia ;

Candal, Arturo .

BJU INTERNATIONAL, 2012, 109 :17-21

[38] Acute and Late Genitourinary Toxicity after 72 Gy of Conventionally Fractionated Conformal Radiotherapy for Localised Prostate Cancer: Impact of Individual and Clinical Parameters [J].

Stankovic, V. ;

Dzamic, Z. ;

Pekmezovic, T. ;

Tepavcevic, D. K. ;

Dozic, M. ;

Saric, M. ;

Vuckovic, S. ;

Nikitovic, M. .

CLINICAL ONCOLOGY, 2016, 28 (09) :577-586

[39] Acute and late genitourinary toxicity of conformal radiotherapy for prostate cancer [J].

Yoshimura R.-I. ;

Iwata M. ;

Shibuya H. ;

Sakai Y. ;

Kihara K. .

Radiation Medicine, 2006, 24 (8) :553-559

[40] Evaluation of clinical and endoscopic toxicity after external beam radiotherapy and endorectal brachytherapy in elderly patients with rectal cancer treated in the HERBERT study [J].

Rijkmans, E. C. ;

van Triest, B. ;

Nout, R. A. ;

Kerkhof, E. M. ;

Buijsen, J. ;

Rozema, T. ;

Franssen, J. H. ;

Velema, L. A. ;

Laman, M. S. ;

Cats, A. ;

Marijnen, C. A. M. .

RADIOTHERAPY AND ONCOLOGY, 2018, 126 (03) :417-423

← 1 2 3 4 5 →