Clinical Correlations between Treatment with Anticoagulants/Antiaggregants and Late Rectal Toxicity after Radiotherapy for Prostate Cancer

被引：1

作者：

Takeda, Ken ^{[1
]}

Ogawa, Yoshihiro ^{[1
]}

Ariga, Hisanori ^{[1
]}

Koto, Masashi ^{[1
]}

Sakayauchi, Toru ^{[1
]}

Fujimoto, Keisuke ^{[1
]}

Narazaki, Kakutaro ^{[1
]}

Mitsuya, Masatoshi ^{[1
]}

Takai, Yoshihiro ^{[2
]}

Yamada, Shogo ^{[1
]}

机构：

[1] Tohoku Univ, Sch Med, Dept Radiat Oncol, Aoba Ku, Sendaishi 9808574, Japan

[2] Tohoku Univ, Sch Med, Dept Radiol Sci, Aoba Ku, Sendaishi 9808574, Japan

来源：

ANTICANCER RESEARCH | 2009年 / 29卷 / 05期

关键词：

Prostate cancer; radiotherapy; late toxicity; rectal toxicity; EXTERNAL-BEAM IRRADIATION; TERM TREATMENT SEQUELAE; CONFORMAL RADIOTHERAPY; ADENOCARCINOMA; MULTICENTER; PREDICTORS; CARCINOMA; 3D-CRT; RTOG;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: To assess variables related to grade 2 or higher late rectal toxicity (LRT) in prostate cancer treated with external radiotherapy. Patients and Methods: A retrospective analysis was carried out of 232 patients with T1-T3 prostate cancer treated with 3-dimensional conformal radiotherapy (3DCRT) (106 patients) or intensity modulated radiotherapy (IMRT) (126 patients) between June 2000 and May 2007. One hundred and seventy-seven patients received androgen deprivation therapy (ADT);fifty patients used anticoagulants/antiaggregants for vascular disease. Results: The median follow-up was 31 months (range, 6-79). At 5 years, the cumulative incidence of grade 2 or 3 LRT was 5.6%. On multivariate analysis, medication with anticoagulants/antiaggregants was correlated with grade 2 or 3 LRT (p=0.027), whereas age, National Comprehensive Cancer Network risk group classification, use of ADT, radiotherapy technique (3DCRT vs. IMRT) and total irradiated dose were not. Conclusion: Treatment with anticoagulants/antiaggregants appears to be a factor in grade 2 or 3 LRT.

引用

页码：1831 / 1834

页数：4

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