A pilot study examining functional brain activity 6 months after memory retraining in MS: the MEMREHAB trial

被引：27

作者：

Dobryakova, Ekaterina ^{[1
,2
]}

Wylie, Glenn R. ^{[1
,2
,3
]}

DeLuca, John ^{[1
,2
,4
]}

Chiaravalloti, Nancy D. ^{[1
,2
]}

机构：

[1] Kessler Fdn Res Ctr, W Orange, NJ 07052 USA

[2] Rutgers New Jersey Med Sch, Dept Phys Med & Rehabil, Newark, NJ USA

[3] War Related Illness & Injury Study Ctr, Dept Vet Affairs, E Orange, NJ USA

[4] Rutgers New Jersey Med Sch, Dept Neurol & Neurosci, Newark, NJ USA

来源：

BRAIN IMAGING AND BEHAVIOR | 2014年 / 8卷 / 03期

关键词：

fMRI; Memory rehabilitation; Clinical trial; MULTIPLE-SCLEROSIS; DEFICITS; FMRI; REHABILITATION;

D O I：

10.1007/s11682-014-9309-9

中图分类号：

R445 [影像诊断学];

学科分类号：

100207 ;

摘要：

Cognitive impairment in individuals with multiple sclerosis (MS) is now well recognized. One of the most common cognitive deficits is found in memory functioning, largely due to impaired acquisition. We examined functional brain activity 6 months after memory retraining in individuals with MS. The current report presents long term follow-up results from a randomized clinical trial on a memory rehabilitation protocol known as the modified Story Memory Technique. Behavioral memory performance and brain activity of all participants were evaluated at baseline, immediately after treatment, and 6 months after treatment. Results revealed that previously observed increases in patterns of cerebral activation during learning immediately after memory training were maintained 6 months post training.

引用

页码：403 / 406

页数：4

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