Mismatches in the Influenza A Virus RNA Panhandle Prevent Retinoic Acid-Inducible Gene I (RIG-I) Sensing by Impairing RNA/RIG-I Complex Formation

被引：14

作者：

Anchisi, Stephanie ^{[1
]}

Guerra, Jessica ^{[1
]}

Mottet-Osman, Genevieve ^{[1
]}

Garcin, Dominique ^{[1
]}

机构：

[1] Univ Geneva, Fac Med, Dept Microbiol & Mol Med, Geneva, Switzerland

来源：

JOURNAL OF VIROLOGY | 2016年 / 90卷 / 01期

基金：

瑞士国家科学基金会;

关键词：

INTERFERON INDUCTION; GENOME; ACTIVATION; INITIATION; MECHANISM; PROMOTER;

D O I：

10.1128/JVI.01671-15

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Influenza virus RNA (vRNA) promoter panhandle structures are believed to be sensed by retinoic acid-inducible gene I (RIG-I). The occurrence of mismatches in this double-stranded RNA structure raises questions about their effect on innate sensing. Our results suggest that mismatches in vRNA promoters decrease binding to RIG-I in vivo, affecting RNA/RIG-I complex formation and preventing RIG-I activation. These results can be inferred to apply to other viruses and suggest that mismatches may represent a general viral strategy to escape RIG-I sensing.

引用

页码：586 / 590

页数：5

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