Age-Related Changes in Extracellular Matrix

被引：16

作者：

Guvatova, Zulfiia G. ^{[1
,2
]}

Borisov, Pavel V. ^{[1
]}

Alekseev, Alexey A. ^{[2
]}

Moskalev, Alexey A. ^{[1
,2
]}

机构：

[1] Russian Acad Sci, Engelhardt Inst Mol Biol, Moscow 119991, Russia

[2] Pirogov Russian Natl Res Med Univ, Russian Clin Res Ctr Gerontol, Minist Healthcare Russian Federat, Moscow 129226, Russia

来源：

BIOCHEMISTRY-MOSCOW | 2022年 / 87卷 / 12-13期

基金：

俄罗斯科学基金会;

关键词：

extracellular matrix; aging; GLYCATION END-PRODUCTS; HEPATIC STELLATE CELLS; GROWTH-FACTOR-BETA; SKELETAL-MUSCLE; CHLOROGENIC ACID; LIVER FIBROSIS; HEART-FAILURE; DIASTOLIC DYSFUNCTION; COLLAGEN TURNOVER; ENTORHINAL CORTEX;

D O I：

10.1134/S0006297922120112

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Extracellular matrix (ECM) is an extracellular tissue structure that, in addition to mechanical support to the cell, is involved in regulation of many cellular processes, including chemical transport, growth, migration, differentiation, and cell senescence. Age-related changes in the structure and composition of the matrix and increase of ECM stiffness with age affect functioning of many tissues and contribute to the development of various pathological conditions. This review considers age-related changes of ECM in various tissues and organs, in particular, effect of ECM changes on aging is discussed.

引用

页码：1535 / 1551

页数：17

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