Radionuclide-Activated Nanomaterials and Their Biomedical Applications

被引：54

作者：

Ferreira, Carolina A. ^{[1
,2
,3
]}

Ni, Dalong ^{[1
,2
,3
]}

Rosenkrans, Zachary T. ^{[1
,2
,3
]}

Cai, Weibo ^{[1
,2
,3
]}

机构：

[1] Univ Wisconsin, Dept Radiol, Madison, WI 53705 USA

[2] Univ Wisconsin, Dept Biomed Engn, Madison, WI 53705 USA

[3] Univ Wisconsin, Dept Med Phys, Madison, WI 53705 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2019年 / 58卷 / 38期

基金：

美国国家卫生研究院;

关键词：

Cerenkov radiation; nanomedicine; radioactivation; radionuclides; theranostics; POSITRON-EMISSION-TOMOGRAPHY; RADIATION ENERGY-TRANSFER; CERENKOV LUMINESCENCE; QUANTUM DOTS; GOLD NANOPARTICLES; IN-VITRO; CHERENKOV RADIATION; CANCER-CELLS; TUMOR UPTAKE; THERAPY;

D O I：

10.1002/anie.201900594

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Radio-nanomedicine, or the use of radiolabeled nanoparticles in nuclear medicine, has attracted much attention in the last few decades. Since the discovery of Cerenkov radiation and its employment in Cerenkov luminescence imaging, the combination of nanomaterials and Cerenkov radiation emitters has been revolutionizing the way nanomaterials are perceived in the field: from simple inert carriers of radioactivity to activatable nanomaterials for both diagnostic and therapeutic applications. Herein, we provide a comprehensive review on the types of nanomaterials that have been used to interact with Cerenkov radiation and the gamma and beta scintillation of radionuclides, as well as on their biological applications.

引用

收藏

页码：13232 / 13252

页数：21

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