Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination

被引：887

作者：

Yu, Jason S. L. ^{[1
]}

Cui, Wei ^{[1
]}

机构：

[1] Imperial Coll London, Inst Reprod & Dev Biol, Dept Surg & Canc, Du Cane Rd, London W12 0NN, England

来源：

DEVELOPMENT | 2016年 / 143卷 / 17期

基金：

英国医学研究理事会;

关键词：

PI3K; AKT; mTOR; Pluripotency; Proliferation and differentiation; Metabolism; EMBRYONIC STEM-CELLS; INCREASED INSULIN SENSITIVITY; MICE LACKING; SELF-RENEWAL; CATALYTIC SUBUNIT; WNT/BETA-CATENIN; SOMATIC-CELLS; GROWTH; MTOR; KINASE;

D O I：

10.1242/dev.137075

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Phosphatidylinositide 3 kinases (PI3Ks) and their downstream mediators AKT and mammalian target of rapamycin (mTOR) constitute the core components of the PI3K/AKT/mTOR signalling cascade, regulating cell proliferation, survival and metabolism. Although these functions are well-defined in the context of tumorigenesis, recent studies - in particular those using pluripotent stem cells - have highlighted the importance of this pathway to development and cellular differentiation. Here, we review the recent in vitro and in vivo evidence for the role PI3K/AKT/mTOR signalling plays in the control of pluripotency and differentiation, with a particular focus on the molecular mechanisms underlying these functions.

引用

页码：3050 / 3060

页数：11

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