Response to chemotherapy is not related to chromosome instability in synovial sarcoma

被引：26

作者：

Chakiba, C. ^{[1
,2
,3
]}

Lagarde, P. ^{[2
,3
,4
]}

Pissaloux, D. ^{[5
]}

Neuville, A. ^{[2
,3
,4
]}

Brulard, C. ^{[3
]}

Perot, G. ^{[3
,4
]}

Coindre, J. M. ^{[2
,3
,4
]}

Terrier, P. ^{[6
]}

Ranchere-Vince, D. ^{[5
]}

Ferrari, A. ^{[7
]}

Collini, P. ^{[8
]}

Suurmeijer, A. J. H. ^{[9
]}

Blay, J. Y. ^{[10
]}

Terrisse, S. A. ^{[11
]}

Piperno-Neumann, S. ^{[12
]}

Averous, G. ^{[13
]}

Bui, B. ^{[1
,3
]}

Orbach, D. ^{[14
]}

Italiano, A. ^{[1
,3
]}

Chibon, F. ^{[3
,4
]}

机构：

[1] Inst Bergonie, Dept Med Oncol, F-33076 Bordeaux, France

[2] Univ Bordeaux 2, F-33076 Bordeaux, France

[3] Inst Bergonie, INSERM, U916, Bordeaux, France

[4] Inst Bergonie, Dept Pathol, Bordeaux, France

[5] Ctr Leon Berard, Dept Pathol, F-69373 Lyon, France

[6] Inst Gustave Roussy, Dept Pathol, Villejuif, France

[7] Fdn IRCCS Ist Nazl Tumori, Dept Med Oncol, Milan, Italy

[8] Fdn IRCCS Ist Nazl Tumori, Dept Pathol, Milan, Italy

[9] Univ Groningen, Univ Med Ctr Groningen, Dept Pathol, Groningen, Netherlands

[10] Ctr Leon Berard, Dept Med Oncol, F-69373 Lyon, France

[11] Inst Gustave Roussy, Dept Med Oncol, Villejuif, France

[12] Inst Curie, Dept Med Oncol, Paris, France

[13] CHU Hautepierre, Dept Pathol, F-67098 Strasbourg, France

[14] Inst Curie, Dept Pediat Oncol, Paris, France

来源：

ANNALS OF ONCOLOGY | 2014年 / 25卷 / 11期

关键词：

synovial sarcoma; genomic index; prognosis; chemotherapy; SOFT-TISSUE SARCOMAS; PHASE-II; RETROSPECTIVE ANALYSIS; PEDIATRIC-ONCOLOGY; ADOLESCENCE; MULTICENTER; CHILDHOOD; IDENTIFICATION; IFOSFAMIDE; SSX;

D O I：

10.1093/annonc/mdu362

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Synovial sarcoma is an aggressive sarcoma subtype characterized by a recurrent translocation t(X;18). We report here that the genomic complexity assessed by comparative genomic hybridization is strongly associated with outcome independently of response to neoadjuvant chemotherapy.Synovial sarcoma (SS) is an aggressive soft-tissue tumor. Despite being considered as a chemosensitive disease, the real impact of perioperative chemotherapy on metastasis-free survival (MFS) is controversial. We have shown that metastatic relapse of SS is strongly associated with genomic complexity. There are no data regarding the potential correlation between genomic complexity and response to chemotherapy. The study population included 65 SS patients diagnosed between 1991 and 2013 and with available tissue material. Genomic profiling was carried out by using array-CGH. Forty-five SS out of the 65 patients were treated with neoadjuvant anthracycline/ifosfamide-based chemotherapy. Radiological response was assessed according to RECIST criteria. Histological response was defined by the percentage of recognizable tumor cells on the surgical specimen. Genomic complexity was significantly associated with MFS. However, there was no statistically significant association between radiological or histological response and genomic complexity. The absence of significant association between response to chemotherapy and genomic complexity suggests that the prognostic value of chromosome instability in SS is independent of response to chemotherapy; mechanisms leading to metastatic relapse of SS are intrinsic to the biology of the tumor and current cytotoxic drugs are only poorly efficient to prevent it.

引用

页码：2267 / 2271

页数：5

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