Extracorporeal photopheresis in acute and chronic graft-versus-host disease

被引：41
作者：
Greinix, Hildegard T. [1 ]
Worel, Nina [2 ]
Just, Ulrike [3 ]
Knobler, Robert [3 ]
机构：
[1] Med Univ Vienna, Dept Internal Med, A-1090 Vienna, Austria
[2] Med Univ Vienna, Dept Blood Grp Serol & Transfus Med, A-1090 Vienna, Austria
[3] Med Univ Vienna, Dept Dermatol, A-1090 Vienna, Austria
来源：
TRANSFUSION AND APHERESIS SCIENCE | 2014年 / 50卷 / 03期
关键词：
Extracorporeal photopheresis; Graft-versus-host disease; REGULATORY T-CELLS; BONE-MARROW; PEDIATRIC-PATIENTS; CLINICAL-RESPONSE; CHRONIC GVHD; PHOTOCHEMOTHERAPY; SURVIVAL; TRANSPLANTATION; DIAGNOSIS; TERM;
D O I：
10.1016/j.transci.2014.04.005
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Graft-versus-host disease (GvHD) is a serious complication of allogeneic hematopoietic cell transplantation causing significant morbidity and mortality. Corticosteroids are the established first-line treatment of GvHD. Patients not responding to corticosteroids have a dismal prognosis. Extracorporeal photopheresis (ECP) has objective activity in the treatment of both acute and chronic corticosteroid-refractory GvHD patients, has an excellent safety profile and is internationally well-established. ECP has been recommended by a significant number of renowned scientific organizations as an efficient treatment option for patients with GvHD. ECP has a proven corticosteroid-sparing effect and favourably impacts on survival and quality of life of responding patients. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：349 / 357
页数：9
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