Bio-reduction of Redox-Sensitive Albumin Conjugates in FcRn-Expressing Cells

被引：16
作者：
Bruelisauer, Lorine [1 ]
Valentino, Gina [1 ]
Morinaga, Sakura [1 ]
Cam, Kuebra [1 ]
Bukrinski, Jens Thostrup [3 ]
Gauthier, Marc A. [2 ]
Leroux, Jean-Christophe [1 ]
机构：
[1] Swiss Fed Inst Technol Zurich ETHZ, Dept Chem & Appl Biosci, Inst Pharmaceut Sci, CH-8093 Zurich, Switzerland
[2] EMT Res Ctr, INRS, Varennes, PQ J3X 1S2, Canada
[3] Novozymes AS, DK-2880 Bagsvaerd, Denmark
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 32期
关键词：
albumin; disulfide; drug delivery; FcRn receptors; reduction; SURFACE THIOLS; DRUG-DELIVERY; HALF-LIFE; IGG; PHARMACOKINETICS; MECHANISM; RECEPTOR; PROTEIN; DEGRADATION; ANTIBODIES;
D O I：
10.1002/anie.201404238
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Disulfide-containing IgG-, Fc-, or albumin-based prodrugs that rely on FcRn-trafficking by endothelial cells for prolonged circulation in the body might be hampered by premature bio-reduction processes during FcRn-mediated recycling events. A detailed bio-reduction analysis of redox-sensitive albumin conjugates in two FcRn-expressing cell lines has been performed. The obtained results indicate that the FcRn-mediated recycling pathway is not (or is only poorly) bio-reducing.
引用
收藏
页码：8392 / 8396
页数：5
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    Wang, Shuo
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    Leroux, Jean-Christophe
    Gauthier, Marc A.
    [J]. BIOMACROMOLECULES, 2013, 14 (07) : 2383 - 2388
  • [42] Interplay of Chemical Microenvironment and Redox Environment on Thiol-Disulfide Exchange Kinetics
    Wu, Chuanliu
    Belenda, Cristina
    Leroux, Jean-Christophe
    Gauthier, Marc A.
    [J]. CHEMISTRY-A EUROPEAN JOURNAL, 2011, 17 (36) : 10064 - 10070
  • [43] A Core-Shell Albumin Copolymer Nanotransporter for High Capacity Loading and Two-Step Release of Doxorubicin with Enhanced Anti-Leukemia Activity
    Wu, Yuzhou
    Ihme, Susann
    Feuring-Buske, Michaela
    Kuan, Seah Ling
    Eisele, Klaus
    Lamla, Markus
    Wang, Yanran
    Buske, Christian
    Weil, Tanja
    [J]. ADVANCED HEALTHCARE MATERIALS, 2013, 2 (06) : 884 - 894
  • [44] Enhanced antibody half-life improves in vivo activity
    Zalevsky, Jonathan
    Chamberlain, Aaron K.
    Horton, Holly M.
    Karki, Sher
    Leung, Irene W. L.
    Sproule, Thomas J.
    Lazar, Greg A.
    Roopenian, Derry C.
    Desjarlais, John R.
    [J]. NATURE BIOTECHNOLOGY, 2010, 28 (02) : 157 - 159
  • [45] Immunoglobulin G (IgG) Expression in Human Umbilical Cord Endothelial Cells
    Zhao, Yingying
    Liu, Yuxuan
    Chen, Zhengshan
    Korteweg, Christine
    Gu, Jiang
    [J]. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 2011, 59 (05) : 474 - 488
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