Bio-reduction of Redox-Sensitive Albumin Conjugates in FcRn-Expressing Cells

被引：16

作者：

Bruelisauer, Lorine ^{[1
]}

Valentino, Gina ^{[1
]}

Morinaga, Sakura ^{[1
]}

Cam, Kuebra ^{[1
]}

Bukrinski, Jens Thostrup ^{[3
]}

Gauthier, Marc A. ^{[2
]}

Leroux, Jean-Christophe ^{[1
]}

机构：

[1] Swiss Fed Inst Technol Zurich ETHZ, Dept Chem & Appl Biosci, Inst Pharmaceut Sci, CH-8093 Zurich, Switzerland

[2] EMT Res Ctr, INRS, Varennes, PQ J3X 1S2, Canada

[3] Novozymes AS, DK-2880 Bagsvaerd, Denmark

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 32期

关键词：

albumin; disulfide; drug delivery; FcRn receptors; reduction; SURFACE THIOLS; DRUG-DELIVERY; HALF-LIFE; IGG; PHARMACOKINETICS; MECHANISM; RECEPTOR; PROTEIN; DEGRADATION; ANTIBODIES;

D O I：

10.1002/anie.201404238

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Disulfide-containing IgG-, Fc-, or albumin-based prodrugs that rely on FcRn-trafficking by endothelial cells for prolonged circulation in the body might be hampered by premature bio-reduction processes during FcRn-mediated recycling events. A detailed bio-reduction analysis of redox-sensitive albumin conjugates in two FcRn-expressing cell lines has been performed. The obtained results indicate that the FcRn-mediated recycling pathway is not (or is only poorly) bio-reducing.

引用

页码：8392 / 8396

页数：5

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