Synthesis, characterization and initial biological studies of a new platinum(II) complex with deoxyalliin

被引：11

作者：

Corbi, Pedro P.

Massabni, Antonio C.

Costa-Neto, Claudio M.

机构：

[1] UNESP, Inst Quim, DQGI, BR-14801970 Araraquara, SP, Brazil

[2] USP, Fac Med Ribeirao Preto, Dept Bioquim & Imunol, BR-14049900 Ribeirao Preto, SP, Brazil

来源：

JOURNAL OF COORDINATION CHEMISTRY | 2006年 / 59卷 / 10期

基金：

巴西圣保罗研究基金会;

关键词：

platinum(II); deoxyalliin; N-15; NMR; cancer therapy;

D O I：

10.1080/00958970500452913

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A new platinum(II) complex with deoxyalliin was synthesized and characterized by chemical and spectroscopic techniques. Elemental and mass spectrometry analyses of the solid complex fit to the composition [Pt(C6H11NO2S)Cl-2] center dot H2O. C-13 NMR, N-15 NMR and infrared spectra of the complex are consistent with coordination of deoxyalliin to Pt( II) through the nitrogen and sulfur atoms forming a square-planar geometry. The complex is soluble in dimethylsulfoxide. Biological analysis for evaluation of a potential cytotoxic effect of the complex was performed using HeLa cells, a human cervix adenocarcinoma-derived cell line. The results were compared with those of a palladium( II) complex previously described.

引用

页码：1101 / 1106

页数：6

共 16 条

[1] Palladium(II) compounds with potential antitumour properties and their platinum analogues: A comparative study of the reaction of some orotic acid derivatives with DNA in vitro [J].