Proton beam radiotherapy: report of the first ten patients treated at the "Centro Nazionale di Adroterapia Oncologica (CNAO)" for skull base and spine tumours

被引：20

作者：

Orecchia, Roberto ^{[1
,2
]}

Vitolo, Viviana ^{[1
]}

Fiore, Maria Rosaria ^{[1
]}

Fossati, Piero ^{[1
,2
]}

Iannalfi, Alberto ^{[1
]}

Vischioni, Barbara ^{[1
]}

Srivastava, Anurita ^{[1
,3
]}

Tuan, Jeffrey ^{[1
,4
]}

Ciocca, Mario ^{[1
]}

Molinelli, Silvia ^{[1
]}

Mirandola, Alfredo ^{[1
]}

Vilches, Gloria ^{[1
]}

Mairani, Andrea ^{[1
]}

Tagaste, Barbara ^{[1
]}

Riboldi, Marco ^{[1
,5
]}

Fontana, Giulia ^{[1
]}

Baroni, Guido ^{[1
,5
]}

Rossi, Sandro ^{[1
]}

Krengli, Marco ^{[1
,6
]}

机构：

[1] Fdn CNAO, I-27100 Pavia, Italy

[2] European Inst Oncol, Milan, Italy

[3] Medanta Medicity, Medanta Canc Inst, Gurgaon, India

[4] Natl Canc Ctr Singapore, Singapore, Singapore

[5] Politecn Milan, Dipartimento Elettron Informaz & Bioingn, I-20133 Milan, Italy

[6] Univ Piemonte Orientale, Dept Translat Med, Novara, Italy

来源：

RADIOLOGIA MEDICA | 2014年 / 119卷 / 04期

关键词：

Proton therapy; Skull base; Spine; Chordoma; Chondrosarcoma; Hadrontherapy; RADIATION-THERAPY; CLINICAL-EXPERIENCE; CHORDOMAS; CHONDROSARCOMAS; MANAGEMENT;

D O I：

10.1007/s11547-013-0345-0

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Purpose The Italian National Centre for Oncological Hadrontherapy (Centro Nazionale di Adroterapia Oncologica, CNAO), equipped with a proton and ion synchrotron, started clinical activity in September 2011. The clinical and technical characteristics of the first ten proton beam radiotherapy treatments are reported. Materials and methods Ten patients, six males and four females (age range 27-73 years, median 55.5), were treated with proton beam radiotherapy. After one to two surgical procedures, seven patients received a histological diagnosis of chordoma (of the skull base in three cases, the cervical spine in one case and the sacrum in three cases) and three of low-grade chondrosarcoma (skull base). Prescribed doses were 74 GyE for chordoma and 70 GyE for chondrosarcoma at 2 GyE/fraction delivered 5 days per week. Results Treatment was well tolerated without toxicity-related interruptions. The maximal acute toxicity was grade 2, with oropharyngeal mucositis, nausea and vomiting for the skull base tumours, and grade 2 dermatitis for the sacral tumours. After 6-12 months of follow-up, no patient developed tumour progression. Conclusions The analysis of the first ten patients treated with proton therapy at CNAO showed that this treatment was feasible and safe. Currently, patient accrual into these as well as other approved protocols is continuing, and a longer follow-up period is needed to assess tumour control and late toxicity.

引用

页码：277 / 282

页数：6

共 21 条

[1] EFFECTIVENESS AND SAFETY OF SPOT SCANNING PROTON RADIATION THERAPY FOR CHORDOMAS AND CHONDROSARCOMAS OF THE SKULL BASE: FIRST LONG-TERM REPORT [J].