CYP3A5 and ABCB1 genes and hypertension

被引：27

作者：

Bochud, Murielle ^{[1
,2
]}

Bovet, Pascal ^{[1
,2
]}

Burnier, Michel ^{[2
,3
]}

Eap, Chin B. ^{[4
,5
]}

机构：

[1] CHU Vaudois, Inst Social & Prevent Med, CH-1005 Lausanne, Switzerland

[2] Univ Lausanne, CH-1005 Lausanne, Switzerland

[3] CHU Vaudois, Serv Nephrol, CH-1005 Lausanne, Switzerland

[4] Univ Lausanne, Unite Biochim & Psychopharmacol Clin, Ctr Neurosci Psychiat, Hop Cery, CH-1015 Lausanne, Switzerland

[5] Univ Lausanne, Univ Geneva, Ecole Pharm, CH-1015 Lausanne, Switzerland

来源：

PHARMACOGENOMICS | 2009年 / 10卷 / 03期

关键词：

ABCB1; blood pressure; CYP3A5; dietary salt intake; gene-gene interaction; hypertension; renin-angiotensin system; QUANTITATIVE TRAIT LOCI; CARDIOVASCULAR RISK-FACTORS; MULTIDRUG-RESISTANCE GENE; P-GLYCOPROTEIN EXPRESSION; STAGE RENAL-DISEASE; BLOOD-PRESSURE; CYCLOSPORINE-A; CYTOCHROME-P450; 3A; ALDOSTERONE SYSTEM; SODIUM REDUCTION;

D O I：

10.2217/14622416.10.3.477

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Hypertension is the first single modifiable cause of disease burden worldwide. Genes encoding proteins that are involved in the metabolism (CYP3A5) and transport (ABCB1) of drugs and hormones might contribute to blood pressure control in humans. Indeed, recent data have suggested that CYP3A5 and ABCB1 gene polymorphisms are associated with blood pressure in the rat as well as in humans. Interestingly, the effects of these genes on blood pressure appear to be modified by dietary salt intake. This review summarizes what is known regarding the relationships of the ABCB1 and CYP3A5 genes with blood pressure, and discusses the potential underlying mechanisms of the association. if the role of these genes in blood pressure control is confirmed in other populations and other ethnic groups, these findings would point toward a new pathway for blood pressure control in humans.

引用

页码：477 / 487

页数：11

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