Transforming Growth Factor-β1 in Balkan Endemic Nephropathy

被引：5

作者：

Dukanovic, Ljubica ^{[1
]}

Lezaic, Visnja ^{[1
]}

Miljkovic, Dorde ^{[2
]}

Momcilovic, Miljana ^{[2
]}

Bukvic, Danica ^{[5
]}

Maric, Ivko ^{[5
]}

Miljkovic, Zeljka ^{[3
]}

Marinkovic, Jelena ^{[4
]}

Mostarica-Stojkovic, Marija ^{[3
]}

机构：

[1] Clin Ctr Serbia, Clin Nephrol, Belgrade, Serbia

[2] Inst Biol Res Dr Sinisa Stankovic, Belgrade, Serbia

[3] Inst Microbiol & Immunol, Belgrade, Serbia

[4] Sch Med, Inst Social Med Stat & Hlth Res, Belgrade, Serbia

[5] Inst Endem Nephropathy, Lazarevac, Serbia

来源：

NEPHRON CLINICAL PRACTICE | 2009年 / 111卷 / 02期

关键词：

Plasma TGF-beta(1); Urine TGF-beta(1); Balkan endemic nephropathy; FACTOR-BETA; PLASMA-LEVELS; GLOMERULAR-DISEASES; IGA NEPHROPATHY; RENAL INJURY; GROWTH-FACTOR-BETA-1; TGF-BETA-1; EXPRESSION; LOSARTAN; KIDNEY;

D O I：

10.1159/000191206

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Background/Aim: The aim of this study was to compare plasma and urine transforming growth factor-beta(1) (TGF-beta(1)) levels in patients with different stages of Balkan endemic nephropathy (BEN) with those in patients with primary glomerulonephritis (GN) and healthy controls. Methods: The study involved 47 patients with BEN (30 with manifest BEN and 17 in the early stage of BEN), 12 patients with GN and 10 healthy controls. Plasma and urine TGF-beta(1) was assayed by enzyme-linked immunosorbent assay. Results: The median plasma TGF-beta(1) levels differed nonsignificantly between the groups (4,908-6,442 pg/ml), but individual plasma TGF-beta(1) levels in BEN patients exhibited the highest dispersion. Median urinary TGF-beta(1) excretion (pg/mg creatinine) was significantly higher in patient groups (manifest BEN: 203, early-stage BEN: 341, GN: 775) than in healthy controls (42). No correlation was found between plasma and urine TGF-beta(1) levels or between plasma TGF-beta(1) levels and creatinine clearance for any of the examined groups. Conclusion: Plasma TGF-beta(1) levels in BEN patients extended over the widest range, but no significant differences were found between the median values for the groups. Median urinary TGF-beta(1) excretion was significantly higher in patients with BEN and GN than in healthy controls. Copyright (C) 2009 S. Karger AG, Basel

引用

页码：C127 / C132

页数：6

共 31 条

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BORDER WA, 1994, NEW ENGL J MED, V331, P1286

[2] Prevalence of Balkan endemic nephropathy has not changed since 1971 in the Kolubara Region in Serbia [J].