Immune checkpoint inhibitor associated reactivation of primary membranous nephropathy responsive to rituximab

被引:25
作者
Lin, Jamie S. [1 ]
Wang, Daniel Y. [2 ]
Mamlouk, Omar [1 ]
Glass, William F. [3 ]
Abdelrahim, Maen [4 ,5 ]
Yee, Cassian [6 ,7 ]
Abudayyeh, Ala [1 ]
机构
[1] Univ Texas MD Anderson Canc Ctr, Div Internal Med, Sect Nephrol, Houston, TX 77030 USA
[2] Baylor Coll Med, Dept Internal Med, Sect Hematol Oncol, Houston, TX 77030 USA
[3] Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Dept Pathol & Lab Med, Houston, TX 77030 USA
[4] Houston Methodist Canc Ctr, Inst Acad Med, Dept Med Oncol, Houston, TX USA
[5] Houston Methodist Canc Ctr, Weill Cornell Med Coll, Houston, TX USA
[6] Univ Texas MD Anderson Canc Ctr, Div Canc Med, Dept Melanoma Med Oncol, Houston, TX 77030 USA
[7] Univ Texas MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA
基金
美国国家卫生研究院;
关键词
case reports; immunotherapy; autoimmunity; MALIGNANT PLEURAL MESOTHELIOMA; A(2) RECEPTOR ANTIBODIES; CANCER; CORRELATE; THERAPY; CELLS; RISK;
D O I
10.1136/jitc-2020-001287
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The same mechanisms that mediate antitumor immunity from checkpoint inhibitors (CPIs) can also lead to unintended targeting of normal tissues, characterized as immune-related adverse events (irAEs). Those with pre-existing autoimmune disease are believed to be particularly vulnerable for exacerbating underlying autoimmunity or inducing severe irAEs. We report the first case of CPI-associated reactivation of primary membranous nephropathy (MN) in a patient with pleural mesothelioma responding to immunotherapy. Due to its specificity in targeting B-lymphocytes, rituximab was used to treat primary MN with the expectation that this would not interfere with the benefits gained from T cell-mediated antitumor immunity. Rituximab was effective in treating CPI-associated reactivation of MN, and the patient was successfully rechallenged with nivolumab and maintained stable kidney function and sustained clinical antitumor effect. While exacerbation of pre-existing autoimmune diseases from CPIs is common, therapy for autoimmune reactivation can be rationally directed by an understanding of the immunosuppressive mechanism with goals of cancer treatment.
引用
收藏
页数:5
相关论文
共 28 条
[21]   Membranous glomerulonephritis associated with diffuse malignant pleural mesothelioma: Report of a case [J].
Sakamoto, K ;
Suzuki, H ;
Jojima, T .
SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY, 2000, 30 (12) :1124-1126
[22]   Thrombocytopenia in patients with melanoma receiving immune checkpoint inhibitor therapy [J].
Shiuan, Eileen ;
Beckermann, Kathryn E. ;
Ozgun, Alpaslan ;
Kelly, Ciara ;
McKean, Meredith ;
McQuade, Jennifer ;
Thompson, Mary Ann ;
Puzanov, Igor ;
Greer, John P. ;
Rapisuwon, Suthee ;
Postow, Michael ;
Davies, Michael A. ;
Eroglu, Zeynep ;
Johnson, Douglas .
JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2017, 5
[23]   Tumor-associated B-cells induce tumor heterogeneity and therapy resistance [J].
Somasundaram, Rajasekharan ;
Zhang, Gao ;
Fukunaga-Kalabis, Mizuho ;
Perego, Michela ;
Krepler, Clemens ;
Xu, Xiaowei ;
Wagner, Christine ;
Hristova, Denitsa ;
Zhang, Jie ;
Tian, Tian ;
Wei, Zhi ;
Liu, Qin ;
Garg, Kanika ;
Griss, Johannes ;
Hards, Rufus ;
Maurer, Margarita ;
Hafner, Christine ;
Mayerhoefer, Marius ;
Karanikas, Georgios ;
Jalili, Ahmad ;
Bauer-Pohl, Verena ;
Weihsengruber, Felix ;
Rappersberger, Klemens ;
Koller, Josef ;
Lang, Roland ;
Hudgens, Courtney ;
Chen, Guo ;
Tetzlaff, Michael ;
Wu, Lawrence ;
Frederick, Dennie Tompers ;
Scolyer, Richard A. ;
Long, Georgina V. ;
Damle, Manashree ;
Ellingsworth, Courtney ;
Grinman, Leon ;
Choi, Harry ;
Gavin, Brian J. ;
Dunagin, Margaret ;
Raj, Arjun ;
Scholler, Nathalie ;
Gross, Laura ;
Beqiri, Marilda ;
Bennett, Keiryn ;
Watson, Ian ;
Schaider, Helmut ;
Davies, Michael A. ;
Wargo, Jennifer ;
Czerniecki, Brian J. ;
Schuchter, Lynn ;
Herlyn, Dorothee .
NATURE COMMUNICATIONS, 2017, 8
[24]   Rituximab Treatment of Nivolumab-Induced Bullous Pemphigoid [J].
Sowerby, Laura ;
Dewan, Anna K. ;
Granter, Scott ;
Md, Leena Gandhi ;
LeBoeuf, Nicole R. .
JAMA DERMATOLOGY, 2017, 153 (06) :603-605
[25]   Autoimmune antibodies correlate with immune checkpoint therapy-induced toxicities [J].
Tahir, Salahaldin A. ;
Gao, Jianjun ;
Miura, Yuji ;
Blando, Jorge ;
Tidwell, Rebecca S. S. ;
Zhao, Hao ;
Subudhi, Sumit K. ;
Tawbi, Hussein ;
Keung, Emily ;
Wargo, Jennifer ;
Allison, James P. ;
Sharma, Padmanee .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (44) :22246-22251
[26]   Anti-Phospholipase A2 Receptor Antibodies and Malignancy in Membranous Nephropathy [J].
Timmermans, Sjoerd A. M. E. G. ;
Ayalon, Rivka ;
van Paassen, Pieter ;
Beck, Laurence H., Jr. ;
van Rie, Henk ;
Wirtz, Joris J. J. M. ;
Verseput, Gaico H. ;
Frenken, Leon A. ;
Salant, David J. ;
Tervaert, Jan Willem Cohen .
AMERICAN JOURNAL OF KIDNEY DISEASES, 2013, 62 (06) :1223-1225
[27]   Thrombospondin Type-1 Domain-Containing 7A in Idiopathic Membranous Nephropathy [J].
Tomas, Nicola M. ;
Beck, Laurence H., Jr. ;
Meyer-Schwesinger, Catherine ;
Seitz-Polski, Barbara ;
Ma, Hong ;
Zahner, Gunther ;
Dolla, Guillaume ;
Hoxha, Elion ;
Helmchen, Udo ;
Dabert-Gay, Anne-Sophie ;
Debayle, Delphine ;
Merchant, Michael ;
Klein, Jon ;
Salant, David J. ;
Stahl, Rolf A. K. ;
Lambeau, Gerard .
NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (24) :2277-2287
[28]   Malignant Pleural Mesothelioma [J].
Tsao, Anne S. ;
Wistuba, Ignacio ;
Roth, Jack A. ;
Kindler, Hedy Lee .
JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (12) :2081-2090