Inhibition of HIV-1 gene expression by Sam68ΔC: multiple targets but a common mechanism?

被引：7

作者：

Cochrane, Alan ^{[1
]}

机构：

[1] Univ Toronto, Dept Mol Genet, Toronto, ON, Canada

来源：

RETROVIROLOGY | 2009年 / 6卷

关键词：

NEF; SAM68; RNA; SEQUESTRATION; REPLICATION; MUTANT; REV;

D O I：

10.1186/1742-4690-6-22

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Two recent publications have explored the mechanisms by which a mutant of the host protein Sam68 blocks HIV-1 structural protein synthesis and expands its activity to encompass Nef. Although the two studies propose different mechanisms for the responses observed, it is possible that a common activity is responsible. Understanding how this Sam68 mutant discriminates among the multiple viral mRNAs promises to reveal unique properties of HIV-1 RNA metabolism.

引用

页数：4

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