Inhibition of HIV-1 gene expression by Sam68ΔC: multiple targets but a common mechanism?

被引：7
|
作者：
Cochrane, Alan [1 ]
机构：
[1] Univ Toronto, Dept Mol Genet, Toronto, ON, Canada
来源：
RETROVIROLOGY | 2009年 / 6卷
关键词：
NEF; SAM68; RNA; SEQUESTRATION; REPLICATION; MUTANT; REV;
D O I：
10.1186/1742-4690-6-22
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Two recent publications have explored the mechanisms by which a mutant of the host protein Sam68 blocks HIV-1 structural protein synthesis and expands its activity to encompass Nef. Although the two studies propose different mechanisms for the responses observed, it is possible that a common activity is responsible. Understanding how this Sam68 mutant discriminates among the multiple viral mRNAs promises to reveal unique properties of HIV-1 RNA metabolism.
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页数：4
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