Microfluidic assembly of multistage porous silicon-lipid vesicles for controlled drug release

被引：66

作者：

Herranz-Blanco, Barbara ^{[1
]}

Arriaga, Laura R. ^{[2
]}

Makila, Ermei ^{[1
,3
]}

Correia, Alexandra ^{[1
]}

Shrestha, Neha ^{[1
]}

Mirza, Sabiruddin ^{[1
,2
]}

Weitz, David A. ^{[2
]}

Salonen, Jarno ^{[3
]}

Hirvonen, Jouni ^{[1
]}

Santos, Helder A. ^{[1
]}

机构：

[1] Univ Helsinki, Fac Pharm, Div Pharmaceut Chem & Technol, FI-00014 Helsinki, Finland

[2] Harvard Univ, Sch Engn & Appl Sci, Dept Phys, Cambridge, MA 02138 USA

[3] Univ Turku, Dept Phys & Astron, Lab Ind Phys, FI-20014 Turku, Finland

来源：

LAB ON A CHIP | 2014年 / 14卷 / 06期

基金：

芬兰科学院; 欧洲研究理事会;

关键词：

MESOPOROUS SILICON; IN-VITRO; SURFACE-CHEMISTRY; NANOPARTICLES; DELIVERY; MICROPARTICLES; MICROCAPSULES; POLYMERSOMES; LIPOSOMES; BIOCOMPATIBILITY;

D O I：

10.1039/c3lc51260f

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A reliable microfluidic platform for the generation of stable and monodisperse multistage drug delivery systems is reported. A glass-capillary flow-focusing droplet generation device was used to encapsulate thermally hydrocarbonized porous silicon (PSi) microparticles into the aqueous cores of double emulsion drops, yielding the formation of a multistage PSi-lipid vesicle. This composite system enables a large loading capacity for hydrophobic drugs.

引用

页码：1083 / 1086

页数：4

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