Mechanism of bile acid-regulated glucose and lipid metabolism in duodenal-jejunal bypass

被引：2
作者：
Chai, Jie [1 ]
Zou, Lei [1 ]
Li, Xirui [1 ]
Han, Dali [1 ]
Wang, Shan [1 ]
Hu, Sanyuan [2 ]
Guan, Jie [1 ]
机构：
[1] Shandong Canc Hosp & Inst, Dept Gen Surg, Jinan 250117, Peoples R China
[2] Shandong Univ, Qilu Hosp, Dept Gen Surg, Jinan 250012, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2015年 / 8卷 / 12期
关键词：
Duodenal-jejunal bypass; bile acid; FXR; TGR-5; HIGH-FAT DIET; X-RECEPTOR; GASTRIC BYPASS; INSULIN-RESISTANCE; NUCLEAR RECEPTORS; HOMEOSTASIS; FXR; BIOSYNTHESIS; ACTIVATION; PATHWAY;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Bile acid plays an important role in regulating blood glucose, lipid and energy metabolism. The present study was implemented to determine the effect of duodenal-jejunal bypass (DJB) on FXR, TGR-5expression in terminal ileum and its bile acid-related mechanism on glucose and lipid metabolism. Immunohistochemistry was used to detect relative gene or protein expression in liver and intestine. Firstly, we found that expression of FXR in liver and terminal ileum of DJB group was significantly higher than that in S-DJB group (P<0.05). In addition, DJB dramatically increased the activation of TGR-5 in the liver of rats. Furthermore, PEPCK, G6Pase, FBPase 1 and GLP-1 were up-regulated by DJB. In conclusion, these results showed that bile acid ameliorated glucose and lipid metabolism through bile acid-FXR and bile acid-TGR-5 signaling pathway.
引用
收藏
页码：15778 / 15785
页数：8
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