Contribution of Maternal Immunity to Decreased Rotavirus Vaccine Performance in Low- and Middle-Income Countries

被引:28
作者
Mwila, Katayi [1 ]
Chilengi, Roma [1 ,3 ]
Simuyandi, Michelo [1 ]
Permar, Sallie R. [2 ]
Becker-Dreps, Sylvia [3 ]
机构
[1] Ctr Infect Dis Res Zambia, Lusaka, Zambia
[2] Duke Univ, Dept Pediat, Human Vaccine Inst, Durham, NC 27706 USA
[3] Univ N Carolina, Sch Med, Dept Family Med, Chapel Hill, NC USA
关键词
immunization; low and middle-income countries; maternal; rotavirus; ENVIRONMENTAL ENTERIC DYSFUNCTION; ORAL POLIOVIRUS VACCINES; SOUTH-AFRICAN CHILDREN; T-CELL EPITOPE; BREAST-MILK; DOUBLE-BLIND; MALAWIAN CHILDREN; OPEN-LABEL; IMMUNOGENICITY; EFFICACY;
D O I
10.1128/CVI.00405-16
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The role of maternal immunity, received by infants either transplacentally or orally from breast milk, in rotavirus vaccine (RV) performance is evaluated here. Breastfeeding withholding has no effect on vaccine responses, but higher levels of transplacental rotavirus-specific IgG antibody contribute to reduced vaccine seroconversion. The gaps in knowledge on the factors associated with low RV efficacy in low- and middle-income countries (LMIC) remain, and further research is needed to shed more light on these issues.
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收藏
页数:8
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