Galectin-3 induces death of Candida species expressing specific β-1,2-linked Mannans

被引:172
作者
Kohatsu, Luciana
Hsu, Daniel K.
Jegalian, Armin G.
Liu, Fu-Tong
Baum, Linda G.
机构
[1] Univ Calif Los Angeles, Sch Med, Dept Pathol & Lab Med, Sch Med,Jonsson Comprehens Canc Ctr, Los Angeles, CA 90095 USA
[2] Univ Calif Davis, Dept Dermatol, Sch Med, Sacramento, CA 95817 USA
关键词
D O I
10.4049/jimmunol.177.7.4718
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Lectins play a critical role in host protection against infection. The galectin family of lectins recognizes saccharide ligands on a variety of microbial pathogens, including viruses, bacteria, and parasites. Galectin-3, a galectin expressed by macrophages, dendritic cells, and epithelial cells, binds bacterial and parasitic pathogens including Leishmania major, Trypanosoma cruzi, and Neisseria gonorrhoeae. However, there have been no reports of galectins having direct effects on microbial viability. We found that galectin-3 bound only to Candida albicans species that bear beta-1,2-linked oligomannans on the cell surface, but did not bind Saccharomyces cerevisiae that lacks beta-1,2-linked oligomarmans. Surprisingly, binding directly induced death of Candida species containing specific beta-1,2-linked oligomannosides. Thus, galectin-3 can act as a pattern recognition receptor that recognizes a unique pathogen-specific oligosaccharide sequence. This is the first description of antimicrobial activity for a member of the galectin family of mammalian lectins; unlike other lectins of the innate immune system that promote opsonization and phagocytosis, galectin-3 has direct fungicidal activity against opportunistic fungal pathogens.
引用
收藏
页码:4718 / 4726
页数:9
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