A chondroitin sulfate small molecule that stimulates neuronal growth

被引：132
|
作者：
Tully, SE [1 ]
Mabon, R [1 ]
Gama, CI [1 ]
Tsai, SM [1 ]
Liu, XW [1 ]
Hsieh-Wilson, LC [1 ]
机构：
[1] CALTECH, Dept Chem & Chem Engn, Pasadena, CA 91125 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 25期
关键词：
D O I：
10.1021/ja0484045
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Chondroitin sulfate glycosaminoglycans are sulfated polysaccharides involved in cell division, neuronal development, and spinal cord injury. Here, we report the synthesis and identification of a chondroitin sulfate tetrasaccharide that stimulates the growth and differentiation of neurons. These studies represent the first, direct investigations into the structure-activity relationships of chondroitin sulfate using homogeneous synthetic molecules and define a tetrasaccharide as a minimal motif required for activity. Copyright © 2004 American Chemical Society.
引用
收藏
页码：7736 / 7737
页数：2
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