Microbial transformation of antifertility agents, norethisterone and 17α-ethynylestradiol

被引：19
|
作者：
Choudhary, MI [1 ]
Musharraf, SG [1 ]
Ali, RA [1 ]
Atif, M [1 ]
Atta-ur-Rahman [1 ]
机构：
[1] Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem Sci, Karachi 75270, Pakistan
来源：
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES | 2004年 / 59卷 / 03期
关键词：
norethisterone; 17; alpha-ethynylestradiol; microbial transformation; cephalosporium aphidicola; Cunninghamella elegans;
D O I：
10.1515/znb-2004-0314
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The microbial transformation of oral contraceptive norethisterone (1) by Cephalosporium aphidicola afforded an oxidized metabolite, 17alpha-ethynylestradiol (2), while the microbial transformation of 2 by Cunninghamella elegans yielded several metabolites, 19-nor-17alpha-pregna-1,3,5 (10)trien-20-yne-3,4,17beta-triol (3), 19-nor-17alpha-pregna-1,3,5 (10)-trien-20-yne-3,7alpha,17beta-triol (4), 19-nor-17alpha-pregna-1,3,5 (10)-trien-20-yne-3,11alpha,17beta-triol (5), 19-nor-17alpha-pregna-1,3,5 (10)-trien-20-yne-3,6beta,17beta-triol (6) and 19-nor-17alpha-pregna-1,3,5 (10)-trien-20-yne-3,17beta-diol-6beta-methoxy (7). Metabolite 7 was found to be a new compound. These metabolites were structurally characterized on the basis of spectroscopic techniques.
引用
收藏
页码：319 / 323
页数：5
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