Haenamindole, an unusual diketopiperazine derivative from a marine-derived Penicillium sp KCB12F005

被引：22

作者：

Kim, Jong Won ^{[1
,6
]}

Ko, Sung-Kyun ^{[1
,2
]}

Son, Sangkeun ^{[1
,2
]}

Shin, Kee-Sun ^{[1
]}

Ryoo, In-Ja ^{[1
]}

Hong, Young-Soo ^{[1
,2
]}

Oh, Hyuncheol ^{[5
]}

Hwang, Bang Yeon ^{[6
]}

Hirota, Hiroshi ^{[3
]}

Takahashi, Shunji ^{[3
]}

Kim, Bo Yeon ^{[1
,2
]}

Osada, Hiroyuki ^{[4
]}

Jang, Jae-Hyuk ^{[1
,2
]}

Ahn, Jong Seog ^{[1
,2
]}

机构：

[1] Korea Res Inst Biosci & Biotechnol, Chungbuk 363883, South Korea

[2] Univ Sci & Technol, Dept Biomol Sci, Taejon 305333, South Korea

[3] RIKEN, RIKEN KRIBB Joint Res Unit, Global Res Cluster, Saitama 3510198, Japan

[4] RIKEN CSRS, Chem Biol Res Grp, Saitama 3510198, Japan

[5] Wonkwang Univ, Coll Pharm, Jeonbuk 570749, South Korea

[6] Chungbuk Natl Univ, Coll Pharm, Chungbuk 362763, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2015年 / 25卷 / 22期

基金：

新加坡国家研究基金会;

关键词：

Diketopiperazine alkaloid; Pyrimidoindole; beta-Phenylalanine; Penicillium sp; Marine-derived fungus; CONSTITUENT AMINO-ACIDS; ABSOLUTE-CONFIGURATION; MARFEYS METHOD; LC/MS;

D O I：

10.1016/j.bmcl.2015.09.026

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

During the chemical investigation of marine-derived fungus, an unusual diketopiperazine (DKP) alkaloid, haenamindole (1), was isolated from a culture of the marine-derived fungus Penicillium sp. KCB12F005. The structure of 1, which possesses benzyl-hydroxypiperazindione and phenyl-pyrimidoindole rings system in the molecule, was elucidated by analysis of NMR and MS data. The stereochemistry of 1 was determined by ROESY and advanced Marfey's method. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：5398 / 5401

页数：4

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