Synthesis of new pentaheterocyclic systems based on the triazolo[3,4-a]-2,7-naphthyridine core

被引：0

作者：

Sirakanyan, Samvel N. ^{[1
]}

Spinelli, Domenico ^{[2
]}

Geronikaki, Athina ^{[3
]}

Hakobyan, Elmira K. ^{[1
]}

Kartsev, Victor G. ^{[4
]}

Yegoryan, Hasmik A. ^{[1
]}

Paronikyan, Ervand G. ^{[1
]}

Ghazaryan, Samvel G. ^{[5
]}

Hovakimyan, Anush A. ^{[1
]}

机构：

[1] Natl Acad Sci RA, Sci Technol Ctr Organ & Pharmaceut Chem, Inst Fine Organ Chem, Ave Azatutyan 26, Yerevan 0014, Armenia

[2] Alma Mater Studiorum Univ Bologna, Dept Chem G Ciamician, Via F Selmi 2, I-40126 Bologna, Italy

[3] Aristotle Univ Thessaloniki, Sch Pharm, Thessaloniki 54124, Greece

[4] InterBioScreen, Moscow 119019, Russia

[5] NAS RA, Sci & Prod Ctr Armbiotechnol, Yerevan 0056, Armenia

来源：

ARKIVOC | 2022年

关键词：

Triazolo[3,4-a]-2,7-naphthyridine; pyrimido[4',5':4,5]thieno[2,3-c][1,2,4]triazolo[3,4-a]-2,7-naphthyridines; alkylation; cyclization; pyrazolo[3,4-c][1,2,4]triazolo(tetrazolo)-2,7-naphthyridines; HETEROCYCLIC-SYSTEMS; DERIVATIVES; POTENT; REACTIVITY; INHIBITORS; CHEMISTRY;

D O I：

10.24820/ark.5550190.p011.848

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of new pentaheterocyclic systems based on the triazolo[3,4-a]-2,7-naphthyridine core is described. Thus, by cyclocondensation of thieno[2,3-c][1,2,4]triazolo[3,4-a]-2,7-naphthyridine with formamide, the corresponding thieno[3,2-d]pyrimidine was obtained, starting from which the N-alkyl, 11-chloro and 11-amino(hydrazino) derivatives were synthesized. Furthermore, reaction of pyrazolo[3,4-c][1,2,4]triazolo(tetrazolo)-2,7-naphthyridines, formed via a condensation/cyclization process, with acetylacetone gave new pentaheterocyclic pyrazolo[3,4-c][1,2,4]triazolo(tetrazolo)-2,7-naphthyridine system. [GRAPHICS] .

引用

页码：1 / 10

页数：10

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