Protinase-activated receptors (PARs): crossroads between innate immunity and coagulation

被引：24
作者：
Cirino, Giuseppe
Vergnolle, Nathalie
机构：
[1] Univ Naples Federico II, Fac Pharm, Dept Expt Pharmacol, I-80131 Naples, Italy
[2] Univ Calgary, Fac Med, Dept Pharmacol & Therapeut, Calgary, AB, Canada
来源：
CURRENT OPINION IN PHARMACOLOGY | 2006年 / 6卷 / 04期
关键词：
D O I：
10.1016/j.coph.2006.05.001
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Coagulation cascade and innate immunity are intimately linked in their endeavor to organize the body's response to injury. Protease-activated receptors (PARs) are important mediators of inflammatory response that can be activated by proteases of the coagulation cascade. Their recent discovery has shed new light on the crosstalk between coagulation and innate immunity. Recent studies have investigated the physiological relevance of PARs in the context of immunity and vascular injury, suggesting that these receptors could be used as therapeutic targets for the treatment of pathologies related to innate immunity, endothelial functions and coagulation processes.
引用
收藏
页码：428 / 434
页数：7
相关论文
共 44 条
[31]   Thrombin responses in human endothelial cells - Contributions from receptors other than Par1 include the transactivation of Par2 by thrombin-cleaved Par1 [J].
O'Brien, PJ ;
Prevost, N ;
Molino, M ;
Hollinger, MK ;
Woolkalis, MJ ;
Woulfe, DS ;
Brass, LF .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (18) :13502-13509
[32]   Role of tissue factor and protease-activated receptors in a mouse model of endotoxemia [J].
Pawlinski, R ;
Pedersen, B ;
Schabbauer, G ;
Tencati, M ;
Holscher, T ;
Boisvert, W ;
Andrade-Gordon, P ;
Frank, RD ;
Mackman, N .
BLOOD, 2004, 103 (04) :1342-1347
[33]   Activation of endothelial cell protease activated receptor 1 by the protein C pathway [J].
Riewald, M ;
Petrovan, RJ ;
Donner, A ;
Mueller, BM ;
Ruf, W .
SCIENCE, 2002, 296 (5574) :1880-1882
[34]   Orchestration of coagulation protease signaling by tissue factor [J].
Riewald, M ;
Ruf, W .
TRENDS IN CARDIOVASCULAR MEDICINE, 2002, 12 (04) :149-154
[35]   Mechanistic coupling of protease signaling and initiation of coagulation by tissue factor [J].
Riewald, M ;
Ruf, W .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (14) :7742-7747
[36]   Gene induction by coagulation factor Xa is mediated by activation of protease-activated receptor 1 [J].
Riewald, M ;
Kravchenko, VV ;
Petrovan, RJ ;
O'Brien, PJ ;
Brass, LF ;
Ulevitch, RJ ;
Ruf, W .
BLOOD, 2001, 97 (10) :3109-3116
[37]   Proteinase-activated receptor-2 mediates arterial vasodilation in diabetes [J].
Roviezzo, F ;
Bucci, M ;
Brancaleone, V ;
Di Lorenzo, A ;
Geppetti, P ;
Farneti, S ;
Parente, L ;
Lungarella, G ;
Fiorucci, S ;
Cirino, G .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2005, 25 (11) :2349-2354
[38]   Protease-activated receptor 2 mediates eosinophil infiltration and hyperreactivity in allergic inflammation of the airway [J].
Schmidlin, F ;
Amadesi, S ;
Dabbagh, K ;
Lewis, DE ;
Knott, P ;
Bunnett, NW ;
Gater, PR ;
Geppetti, P ;
Bertrand, C ;
Stevens, ME .
JOURNAL OF IMMUNOLOGY, 2002, 169 (09) :5315-5321
[39]   The cardiovascular actions of protease-activated receptors [J].
Steinberg, SF .
MOLECULAR PHARMACOLOGY, 2005, 67 (01) :2-11
[40]   Clinical relevance of proteinase activated receptors (PARs) in the gut [J].
Vergnolle, N .
GUT, 2005, 54 (06) :867-874
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