Evaluation of mifepristone as a once a month contraceptive pill

被引：19

作者：

Agarwal, Mukta ^{[1
]}

Das, Vinita ^{[1
]}

Agarwal, Anjoo ^{[1
]}

Pandey, Amita ^{[1
]}

Srivastava, Deepali ^{[1
]}

机构：

[1] CSM Med Univ, Dept Obstet & Gynaecol, Upgraded King Georges Med Univ, Lucknow, Uttar Pradesh, India

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2009年 / 200卷 / 05期

关键词：

contraceptive pill; mifepristone; monthly; PHASE;

D O I：

10.1016/j.ajog.2008.09.005

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

OBJECTIVE: The purpose of this study was to assess the efficacy and safety of mifepristone as a contraceptive pill. STUDY DESIGN: A prospective case-control study was conducted in a tertiary care center of North India. The study group (n = 86) was given 200-mg mifepristone tablets on the 16th day of the menstrual cycle. The control group (n = 92) received combined oral contraceptive (COC) as per protocol. Subjects were followed for drug compliance, satisfaction, side effects, and failure. RESULTS: Acceptability of mifepristone was significantly higher in educated population (P < .001), with fewer side effects (P = .001), good satisfaction (P < .001), and higher compliance rate (P = .05). The oral contraceptive pill group had higher adverse biochemical parameters. CONCLUSION: Mifepristone can be used as a monthly contraceptive pill effectively.

引用

页码：E27 / E29

页数：3

共 6 条

[1]

BEREK JS, 2007, BEREK NOVAKS GYNECOL, P267

[2] A single dose of mifepristone (200 mg) in the immediate preovulatory phase offers contraceptive potential without cycle disruption [J].