CRISPR-Cas systems: beyond adaptive immunity

被引：242
作者：
Westra, Edze R. [1 ]
Buckling, Angus [1 ]
Fineran, Peter C. [2 ]
机构：
[1] Univ Exeter, Penryn TR10 9EZ, Cornwall, England
[2] Univ Otago, Dept Microbiol & Immunol, Dunedin 9054, New Zealand
来源：
NATURE REVIEWS MICROBIOLOGY | 2014年 / 12卷 / 05期
关键词：
DEVELOPMENTALLY-REGULATED GENES; ESCHERICHIA-COLI; ACQUIRED-RESISTANCE; ANTIVIRUS IMMUNITY; STRUCTURAL BASIS; DNA ELEMENTS; RNA; BACTERIOPHAGE; INTERFERENCE; PROTEIN;
D O I：
10.1038/nrmicro3241
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The discovery of CRISPR-Cas (clustered, regularly interspaced short palindromic repeats-CRISPR-associated proteins) adaptive immune systems in prokaryotes has been one of the most exciting advances in microbiology in the past decade. Their role in host protection against mobile genetic elements is now well established, but there is mounting evidence that these systems modulate other processes, such as the genetic regulation of group behaviour and virulence, DNA repair and genome evolution. In this Progress article, we discuss recent studies that have provided insights into these unconventional CRISPR-Cas functions and consider their potential evolutionary implications. Understanding the role of CRISPR-Cas in these processes will improve our understanding of the evolution and maintenance of CRISPR-Cas systems in prokaryotic genomes.
引用
收藏
页码：317 / 326
页数：10
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