Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function

被引：172

作者：

Wang, Chenguang

Li, Zhiping

Lu, Yinan

Du, Runlei

Katiyar, Sanjay

Yang, Jianguo

Fu, Maofu

Leader, Jennifer E.

Quong, Andrew

Novikoff, Phyllis M.

Pestell, Richard G. ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Kimmel Canc Ctr, Dept Canc Biol, Philadelphia, PA 19107 USA

[2] Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10461 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2006年 / 103卷 / 31期

关键词：

mitochondria; phosphorylation;

D O I：

10.1073/pnas.0603363103

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cyclin D1 promotes nuclear DNA synthesis through phosphorylation and inactivation of the pRb tumor suppressor. Herein, cyclin D1 deficiency increased mitochondrial size and activity that was rescued by cyclin D1 in a Cdk-dependent manner. Nuclear respiratory factor 1 (NRF-1), which induces nuclear-encoded mitochondrial genes, was repressed in expression and activity by cyclin D1. Cyclin D1-dependent kinase phosphorylates NRF-1 at S47. Cyclin D1 abundance thus coordinates nuclear DNA synthesis and mitochondrial function.

引用

收藏

页码：11567 / 11572

页数：6

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