A platform for nitric oxide delivery

被引：140
作者：
Kim, Jihoon [1 ]
Saravanakumar, Gurusamy [1 ]
Choi, Hyung Woo [1 ]
Park, Dongsik [1 ]
Kim, Won Jong [1 ]
机构：
[1] Pohang Univ Sci & Technol, Ctr Self Assembly & Complex, Inst Basic Sci, Dept Chem, Pohang 790784, South Korea
来源：
JOURNAL OF MATERIALS CHEMISTRY B | 2014年 / 2卷 / 04期
关键词：
SELF-ASSEMBLED MONOLAYERS; DRUG-DELIVERY; SILICA NANOPARTICLES; GOLD NANOPARTICLES; S-NITROSOTHIOLS; VISIBLE-LIGHT; NO-DONORS; IN-VITRO; SOL-GELS; !text type='JS']JS[!/text]-K;
D O I：
10.1039/c3tb21259a
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Nitric oxide (NO) is one of the structurally smallest pharmaceutical molecules, which shows great potential as an anti-restenosis, wound healing, anticancer, and antibacterial agent. To date, while most of the studies have focused mainly on demonstrating the versatility of the NO-releasing materials, little effort has been made on developing successful NO-delivery strategies for advancing NO-mediated therapy. Thus, the quest for a rationally designed NO-delivery system is becoming one of the important issues in the biomedical applications of NO. This feature article discusses the overall research trends in the NO-delivery, focusing mainly on the various particle-type and coating platforms. The objective of this article is not only to highlight the fundamental principle and challenges associated with NO-delivery, but also to provide insight for the further development of novel NO-delivery platforms for clinical applications in the near future.
引用
收藏
页码：341 / 356
页数：16
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