Synthesis and antimicrobial evaluation of novel derivatives of 1,3,4-thiadiazine incorporated with pyrazole-4-carboxylic acid moiety

被引：0

作者：

Shubakar, K. ^{[1
]}

Umesha, K. B. ^{[1
]}

Srikantamurthy, N. ^{[1
]}

Chethan, J. ^{[2
]}

机构：

[1] Univ Mysore, Yuvarajas Coll, Dept Chem, Mysore 570005, Karnataka, India

[2] Univ Mysore, Dept Studies Biotechnol, Mysore 570006, Karnataka, India

来源：

BULGARIAN CHEMICAL COMMUNICATIONS | 2013年 / 45卷 / 03期

关键词：

2-amino-1,3,4-thiadiazine; pyrazole-4-carboxylic acid; antimicrobial;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

2-Amino-5-phenyl-6H-[1,3,4]-thiadiazine (5a-c) condense with pyrazole-4-carboxylate (la-e) using alcohol as a solvent to give 5-methyl-1,3-diphenyl-1H-pyrazole-4-carboxylic acid-(5-phenyl-6H-[1,3,4]-thiadiazin-2-yl)-amide (6a-i) in 30% yield. The same product is obtained from pyrazole-4-acid (2a-e) in presence of HOBt (1-hydroxy-benzotriazole) and EDC (N-ethyl-N'-(3-dimethyl-aminopropyl)-carbodiimide hydrochloride) in triethyl amine using CHCl3 as a solvent, in 75-85% yields. The structures of these compounds (6a-i) were characterized by FT-IR, H-1 NMR, mass spectroscopic techniques and elemental analysis. All synthesized pyrazole-1,3,4-thiadiazine (6a-i) derivatives were found to exhibit antimicrobial activities.

引用

页码：274 / 279

页数：6

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